DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgre10

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_021333746.1	Gene:	adgre10 / 569655	ZFINID:	ZDB-GENE-090313-152	Length:	690	Species:	Danio rerio

Alignment Length:	622	Identity:	136/622 - (21%)
Similarity:	241/622 - (38%)	Gaps:	129/622 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 ADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDALP 251
            ||||.|      |.:...|.|....||::.:.|.:...:||.|:...|..:.:|...|.::
Zfish   153 ADVHTT------LEEACTDWTAKDCLVNILELIENITVQVLPLNTVTNYLDMVLEATEKFL---- 207

  Fly   252 EQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALI-----TGNISVFFANPECDRITG 311
                        |:..:...||.|:.|......::..:..|:     :.|:|....|.|     |
Zfish   208 ------------VSSSSDSPAELASYGNRVLESTEKLISTLVKLTDTSANVSFTLENVE-----G 255

  Fly   312 LAIFSAPGD------QRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLP----ENLWRQVKSR 366
            ......|..      |..|:.|......|    .:||..:::.....||:.    |||.:
Zfish   256 HVFMVGPNVTLNEILQLNTTNSFMDIDLI----GIAKNNKDTRSAAVAFMSYTIMENLLK----- 311

  Fly   367 GATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAF 431
                         |.|..|.....:...|.|||.::|...:..|:.|:.|..|:....:|.
Zfish   312 -------------ADFFNTQKNTNKTMMSTVISATLPKTSNTALTKPVNFTFRHIREFDPS---- 359

  Fly   432 SIGS-GCGYWNYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITP 495
              || .|.|||...|..:|.|..:|:    .:...|...||:.||.::..|           .:|
Zfish   360 --GSLSCVYWNISEWIVDGCSVLNSN----SSHTVCSCVHLSTFALIMQTS-----------SSP 407

  Fly   496 INEKVLDIISIVGCSLSLLGILGIFLTAALFK----SWRSQASTKVLLHLCLAMCLQMMLFVFLN 556
            ....:||::::| |  .::|:  :|.:.||..    .|....:....:::|::: |...|.:.|.
Zfish   408 PPSDLLDLLNLV-C--VIVGL--VFFSLALLSFALCQWSPGVNNVARINICISL-LSAHLLLLLT 466

  Fly   557 TDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILK---A 618
            ...:|   ::....|.||.:...:.:..|..|.||.|.|.|.|.....:..:....:.:|.   .
Zfish   467 QQFLS---LIRPQQVLCVVIAGLLHFLFLSAFVWMFIEAVLLFICVKNLSQVSSRKKEVLSNGFL 528

  Fly   619 AIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVY 683
            .::.:::.|:...:...:.|:.|......:..|.        |..:..:.||.:|...|:::|:
Zfish   529 CVIGYVVALIGVSVSIGMVPEGYGSEQCWIKMDK--------GFFWSFLGPVCVILGLNVILFI- 584

  Fly   684 VFYSISHSLSQSIHK-NEKKMVVKQIRLSIM----LFFLLGLTWIFGIFAFMQAGVAFSYLFCIT 743
               |||..|:.::.| |.:...:||.::.:.    .|.:||..||.|.||  ...:....:|.|.
Zfish   585 ---SISIYLNSALKKLNAEVSQLKQTKVMVFKTLGQFVILGCPWILGFFA--HVNMVVEIVFIII 644

  Fly   744 ATMQG-FVMFIYFVLLDSTN-----RRLWVGLICPTK 774
            .:.|| |:..||.||  ||.     ::::..|.|..|
Zfish   645 NSQQGTFIFLIYCVL--STEIRQQYKKIFTCLCCGCK 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/37 (30%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	56/262 (21%)
adgre10	XP_021333746.1	GPS	360..406	CDD:197639	16/60 (27%)
		7tm_GPCRs	413..672	CDD:333717	63/283 (22%)
		TM helix 1	413..437	CDD:320095	8/28 (29%)
		TM helix 2	446..467	CDD:320095	4/21 (19%)
		TM helix 3	481..503	CDD:320095	6/21 (29%)
		TM helix 4	527..543	CDD:320095	1/15 (7%)
		TM helix 5	561..584	CDD:320095	6/30 (20%)
		TM helix 6	608..631	CDD:320095	6/22 (27%)
		TM helix 7	635..660	CDD:320095	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4884
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.860