Protein Alignment Mayo and adgrl1a

DIOPT Version :10

• Sequence 1: NP_651842.3
• Gene: Mayo / 43678
• FlyBaseID: FBgn0039818
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: XP_073801064.1
• Gene: adgrl1a / 562531
• ZFINID: ZDB-GENE-131127-267
• Length: 1524
• Species: Danio rerio
• Alignment Length: 698
• Identity: 145/698 - (20%)
• Similarity: 241/698 - (34%)
• Gaps: 221/698 - (31%)

  Fly   190 HMTGQMFGALMQQDKDATVSVDLVSVCKEIMSCDSKVLR------------------------LS 230
            |..|::...      |.:.||.|:....:|:....:.||                        :.
Zfish   556 HTQGRIHAG------DVSSSVRLIEQLLDILDAQLQALRPGNKESAARNYNKWQKRERTCRAYVQ 614

  Fly   231 AQLNATNSLL--SQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVET------------ 281
            |.:...::||  ...||:.|                 ..::::|.|||..::.
Zfish   615 AVVQTVDNLLRAEALESWQD-----------------MNSTEQAHTATMLLDVMEKGAFLLANNM 662

  Fly   282 YN--FSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLA--- 341
            ||  |||.....    ::.|...|.|.|                             |:||:
Zfish   663 YNNHFSDHAANV----DLEVRVLNTETD-----------------------------SQDLSFPQ 694

  Fly   342 KVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKP------------R 394
            ....:|:::.:|    :.::|....|...::|.:|.:...|:.|.....:..            .
Zfish   695 SGPSDSSIQLSA----STFKQYSRNGQVKVVFVLYKNLGSFLSTENATVKMEMEAGIGGRGLAVN 755

  Fly   395 SKVISISIPGLRSN-YLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNYE------TWSTEG--- 449
            |.||:.||....|. :|:.|:.|.||:..|.|      .....|.:|||.      .||::|
Zfish   756 SHVIAASINKESSRVFLTEPVVFTLRHLQLEN------HFSPNCSFWNYSERSMTGQWSSQGCRL 814

  Fly   450 VSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLL 514
            :.|.|:.       ..|..:|||.||.|:  .:...|....     ::|.:|.:|:.||..:||
Zfish   815 IETNSTH-------TTCSCSHLTNFAVLM--VHHEPDYPGR-----MHELILFVITWVGIVISL- 864

  Fly   515 GILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFV-FLNTDD------------VSEALVV 566
                                      :|||:|:....|: .|.||.            ::|.|.:
Zfish   865 --------------------------VCLAICISTFCFLRGLQTDRNTIHKNLCINLFIAELLFL 903

  Fly   567 NG-----NTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIE--RPPRYILKAAIVAWL 624
            .|     ..:.|......:.:..|..||||.:.....:...|.|...|  |...|.|    ..:.
Zfish   904 IGIDKTQYHIACPIFAGLLHFFFLAAFSWMCLEGIQLYLMLVEVFESEYSRKKYYYL----CGYC 964

  Fly   625 LPLVPTLLVALIDPDSY-VPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYSI 688
            .|.:...:.|.||..|| ...|..|..|       .| .|:..:.||:.|.:.|||..:...:.:
Zfish   965 FPALVVGISAAIDYRSYGTKKACWLRVD-------NY-FIWSFIGPVSFIIMLNLVFLMITLHKM 1021

  Fly   689 SHSLSQSIHKNEKKMVVKQIRL-SIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMF 752
            ..:.|.....:.:...:|...| :|.|.|||||||.||:....:..|..:|||......||..:|
Zfish  1022 IRNSSALKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINENTVIMAYLFTTFNAFQGMFIF 1086

  Fly   753 IYFVLLDSTNRRLWVGLICPTKMELDVQK--RTTELQSMTTSSTNYNS 798
            |:...|..             |:..:..|  |.:...|.|::::::.|
Zfish  1087 IFHCALQK-------------KVHKEYSKCLRHSYCCSRTSTTSSHGS 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mayo	NP_651842.3	7tmB2_Adhesion	498..766	CDD:320168	70/289 (24%)
		TM helix 1	500..525	CDD:320168	6/24 (25%)
		TM helix 2	535..557	CDD:320168	6/22 (27%)
		TM helix 3	574..600	CDD:320168	5/25 (20%)
		TM helix 4	615..635	CDD:320168	2/19 (11%)
		TM helix 5	659..688	CDD:320168	8/28 (29%)
		TM helix 6	704..730	CDD:320168	13/26 (50%)
		TM helix 7	734..759	CDD:320168	8/24 (33%)
adgrl1a	XP_073801064.1	None