DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgrg6

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001356058.1	Gene:	adgrg6 / 561970	ZFINID:	ZDB-GENE-041014-357	Length:	1208	Species:	Danio rerio

Alignment Length:	873	Identity:	185/873 - (21%)
Similarity:	324/873 - (37%)	Gaps:	248/873 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NGTFQ------YCDGEERNSSDELMQTHLVY--CTSMFCEPEEFQH--------------DYITR 75
            |.|||      |.||....::.::....|||  .|.:.....|.:.              |.:|.
Zfish   406 NQTFQNWMYRVYVDGIRITTTRQIYLALLVYKNTTDVNLAEVEIESMLRSAPAIGNGLTLDSVTV 470

  Fly    76 N------HDQTPHQNKWKRARIGERATLHDVCLLRNGMPVTRECRVKDNRANWESTEHWDPVVCL 134
            |      .|:.|...:|..:|  ...|.:..|........:|.|.:  ||.|:  |..|
Zfish   471 NLMENCQADEFPVHYRWPESR--PTVTQYVPCFPYKDRNASRTCMI--NRDNY--TSFW------ 523

  Fly   135 RRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGAL 199
                         :|.|       |.|.|    .:|.|                          .
Zfish   524 -------------ALPD-------RGNCT----NITSI--------------------------T 538

  Fly   200 MQQDKDATVSVDLVSVC------KEIMSCDSKVLRL--SAQLNAT----------NSLLSQFESY 246
            :.|:....|:|.|..:.      :|:....:||:.|  .|::|||          |.::|..::.
Zfish   539 VSQENAMDVAVQLADISNNGLSKEELTQVVTKVMELVNIAKINATLASTVVTIISNVMVSSEDAQ 603

  Fly   247 MDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALITGN-----ISVFFA---- 302
            .||....|...|...:.:      |.:..:..:.:.|.. :||.||.|.|     :|.|.|
Zfish   604 KDASETALKAVDELVQKI------EFDGPSLTISSKNLV-VGVSALDTTNFNGSTLSAFIATNTT 661

  Fly   303 NPECD----RITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQV 363
            :|:.|    ....||:.:.|....:..:             |:::::.|.:....|....|::..
Zfish   662 DPQIDFDSEAHNALAVVTLPPTLLQNLS-------------LSQIEKVSRINFMFFGRTGLFQDH 713

  Fly   364 KSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRN-ENLRNPD 427
            ::.|.|.                       .|.|::.|:.......|..|:...:.: |..::|:
Zfish   714 QNNGLTL-----------------------NSYVVASSVGNFTIKNLQDPVRIEIAHLEYQKDPN 755

  Fly   428 SKAFSIGSGCGYWNYET------WSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRAND 486
            .:       |.:|::..      |:::|....|.|:..:..   |..||||.|..|:..|..|.
Zfish   756 PQ-------CVFWDFNLQNYSGGWNSDGCKVGSDSNSNRTV---CLCNHLTHFGILMDVSRAAE- 809

  Fly   487 LGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMML 551
                 ||...|.:||..|:.:||.:|.:......||...|:..|....:|:|::|..::....|:
Zfish   810 -----LIDEKNNRVLTFITYIGCGISAIFSAATLLTYIAFEKLRRDYPSKILMNLSTSLLFLNMV 869

  Fly   552 FV---FLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWM------LIIAFLQ-FQRYVTVI 606
            |:   :|.:.::.|.         ||.:...:.:.:|..|:||      :.||.:: |..|:.
Zfish   870 FLLDGWLASYEIKEL---------CVTVAVFLHFFLLTSFTWMGLESIHMYIALVKVFNTYIR-- 923

  Fly   607 GIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTD----TGICYPSGYGLIFGVV 667
                  |||||..||.|.:|.....:|..:..|||..:......|    :..|:     ::..||
Zfish   924 ------RYILKFCIVGWGVPAAIVGIVLAVSKDSYGKNYYGKGKDGQGTSEFCW-----ILNPVV 977

  Fly   668 LPVT------LITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGI 726
            ..||      :|.:.|:.:|:.|...|.....:..::..::.:::.:|..:.|.||||:||.|..
Zfish   978 FYVTCVAYFSIIFLMNVAMFIVVMIQICGRNGKRSNRTLREDILRNLRSVVSLTFLLGMTWGFAF 1042

  Fly   727 FAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMEL----DVQKRTT--- 784
            ||:....:||.|||.|..::||..:|::...|....::.|...:|..|:.|    |..|..|
Zfish  1043 FAWGPVSLAFMYLFTIFNSLQGLFIFVFHCALKENVQKQWRRYLCCGKLRLADNSDWSKTATNNT 1107

  Fly   785 ----------ELQSMTTSST--NYNSRS 800
                      .|.|.:..||  |:.|::
Zfish  1108 KKVSSDNLGKSLSSSSFGSTTANWTSKA 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/43 (26%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	70/269 (26%)
adgrg6	NP_001356058.1	CUB	41..146	CDD:278839
		LamG	153..336	CDD:354964
		GPS	756..801	CDD:334696	12/54 (22%)
		7tmB2_GPR126	816..1086	CDD:320662	73/291 (25%)
		TM helix 1	818..843	CDD:320662	8/24 (33%)
		TM helix 2	853..875	CDD:320662	5/21 (24%)
		TM helix 3	886..913	CDD:320662	5/26 (19%)
		TM helix 4	928..944	CDD:320662	5/15 (33%)
		TM helix 5	975..998	CDD:320662	6/22 (27%)
		TM helix 6	1021..1046	CDD:320662	11/24 (46%)
		TM helix 7	1050..1075	CDD:320662	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5962
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910