DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgre4

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_631877.2	Gene:	Adgre4 / 52614	MGIID:	1196464	Length:	689	Species:	Mus musculus

Alignment Length:	665	Identity:	151/665 - (22%)
Similarity:	247/665 - (37%)	Gaps:	213/665 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 VCKEIMSCDSKV--------------------------------LRLSAQLNATNSLLSQFESYM 247
            |||::..|.:|:                                .:.:.....|..:||:|:|
Mouse    87 VCKDVSYCRNKIGTYICSCVVKYPLFNWVAGIINIDHPDCYVNKSKNTGSKTHTLGVLSEFKS-- 149

  Fly   248 DALPEQLVPKDRCGKVVAK----------------PTSDEAETATTGVETYNFSDIGVQALITGN 296
                     |:...|...|                |..||...
Mouse   150 ---------KEEVAKGATKLLRKVEHHILNENSDIPKKDENPL---------------------- 183

  Fly   297 ISVFFANPECDRITGLAIFSAPGDQRKTS-ASGFWYRFIRFSEDLAKVKE-ESNLETA-AFLPEN 358
            :.:.:....|..:|   :..|..:..|.. .|||              || .|..||| ||:
Mouse   184 LDIVYETKRCKTMT---LLEAGNNTMKVDCTSGF--------------KEHNSGGETAVAFI--- 228

  Fly   359 LWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENL 423
               ..||.| ..|....::::..|.|.:|      .|.::|.:|.......||.|:  ||..:|:
Mouse   229 ---AYKSLG-NLLNGSFFSNEEGFQEVTL------NSHIVSGAIRSEVKPVLSEPV--LLTLQNI 281

  Fly   424 RNPDSKAFSIGSGCGYWNYE----TWSTEGVS---TESSSDLLKDAIIECHTNHLTQFAFLVGGS 481
            :..||:|..:   |.:|...    :|||:|.|   |.:|..:       |...||:.||.|
Mouse   282 QPIDSRAEHL---CVHWEGSEEGGSWSTKGCSHVYTNNSYTI-------CKCFHLSSFAVL---- 332

  Fly   482 YRANDLGEEILITPINE----KVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLC 542
                      :..|..|    ..|.:|:.||.||||   |.:||.|..|...|...:|...|||.
Mouse   333 ----------MALPHEEDGVLSALSVITYVGLSLSL---LCLFLAAITFLLCRPIQNTSTTLHLQ 384

  Fly   543 LAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQ-FQRYVTVI 606
            |::||.:...:||...:.::..|:      |..:...:.|..|..|.||    ||: ...::||.
Mouse   385 LSICLFLADLLFLTGINRTKPKVL------CSIIAGMLHYLYLASFMWM----FLEGLHLFLTVS 439

  Fly   607 GIERPPRYILKAAIVA--------WLLPL---VPTLLVALIDPDSYVPSAAQLSTDTGICYPSGY 660
            .        ||.|..:        ::.|:   :|..:||:    |.:.......|... |:.|.:
Mouse   440 N--------LKVANYSNSGRFKKRFMYPVGYGLPAFIVAV----SAIAGHKNYGTHNH-CWLSLH 491

  Fly   661 -GLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHK------NEKKMVVKQIRLSIMLFFLL 718
             |.|:..:.|...|.:.|||.:..:.:.:...|| |::|      :.|.|..|    :|:..|:|
Mouse   492 RGFIWSFLGPAAAIILINLVFYFLIIWILRSKLS-SLNKEVSTLQDTKVMTFK----AIVQLFVL 551

  Fly   719 GLTWIFGIFAFMQAG----VAFSYLFCITATMQGFVMFIYFVLLDSTNR---RLWVGLICPTKME 776
            |.:|..|:|.|::.|    :..:|||.|...:||.::|:...||:...|   :.|.     .::.
Mouse   552 GCSWGIGLFIFIEVGKTVRLIVAYLFTIINVLQGVLIFMVHCLLNRQVRMEYKKWF-----HRLR 611

  Fly   777 LDVQKRTTELQSMTT 791
            .:|:..:||:...||
Mouse   612 KEVESESTEVSHSTT 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/44 (27%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	74/272 (27%)
Adgre4	NP_631877.2	EGF_CA	77..>105	CDD:214542	5/17 (29%)
		GAIN	<214..262	CDD:293098	18/74 (24%)
		GPS	290..332	CDD:280071	14/51 (27%)
		7tm_4	343..588	CDD:304433	74/275 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810