DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgrl4

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_998532.2	Gene:	adgrl4 / 406676	ZFINID:	ZDB-GENE-040426-2689	Length:	735	Species:	Danio rerio

Alignment Length:	778	Identity:	167/778 - (21%)
Similarity:	273/778 - (35%)	Gaps:	225/778 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DPVVCLRRFREHTISGDLNSLHDDVLEGR-----------RRTNDTQGRREMTGIMRNMFRQRGG 182
            ||  |  ||.:...|...|:..||:.:.|           |..|:.:...|:.|:..|.....||
Zfish    23 DP--C--RFLDICQSCHPNADCDDICKCRTGYTGNGISDCRDDNECETVPEICGLHANCTNYVGG 83

  Fly   183 ---NLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSC--DSKVLRLSAQLNATNSLLSQ 242
               |.|...:....:.|     |..|.| |.:.::.|:|...|  :||     ...|..:.:.|.
Zfish    84 YYCNCLSGFISNGTEQF-----QTNDGT-SCNDINECEEDRKCGPNSK-----CHNNIGSFICSC 137

  Fly   243 FESYMDALPEQLVPK----------------DRCGKVVAKPTSD----------------EAETA 275
            ...|........:|.                .:|.|.....|.:                :...|
Zfish   138 LRGYTSPAGPWFMPNHGTDCIENSKIHCHQDHKCTKETVNSTLERMTNLSISERLKEIRYQTSAA 202

  Fly   276 TTGVETYNFSDIGVQA-LITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSED 339
            .:.|...::.:..|.: |.:|::|........:.||.| :||......|...    ..:.:.:||
Zfish   203 LSPVLLISYIEAMVSSKLNSGDVSKDSKEHVNETITNL-VFSVNNLVEKDEK----VEWKKINED 262

  Fly   340 L-----AKVKEESNLETAAF---------------------------------LPENLW------ 360
            |     .|:...:..||.|.                                 |..|:.
Zfish   263 LRMYYVTKLLHTAEKETLALSAGYTHATQMQVHAGDVEMKLYTFEPRQAQKHPLSANIQGNSISL 327

  Fly   361 -----RQVKSRGATYLIFKVYAHDALFVETSLQRTRKP--------------------RSKVISI 400
                 |...:.|:|.::|.:| |       |:....||                    .|.||:.
Zfish   328 STKKARHANNNGSTSVVFLIY-H-------SIGDLLKPADDPGVADYSRYAAAGEITVNSPVIAA 384

  Fly   401 SIPGLRSNYLSLPL---PFLLRNENLRNP---DSKAFSIGSGCGYWNYET-----WSTEG----- 449
            :|    ||..:|||   .|.|::....:|   ::|       |.:|.|..     ||.:|
Zfish   385 AI----SNQKTLPLNDVTFTLKHTQEIDPARDETK-------CAFWEYSPSMMGHWSLDGCIRTR 438

  Fly   450 VSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLL 514
            |:|..:|         |..||||.||.|: .|.|||.|....::|.|.:        :|..:||
Zfish   439 VNTTHTS---------CSCNHLTHFAILM-SSARANLLAHYNVLTRITQ--------LGMVISL- 484

  Fly   515 GILGIFLTAALFKSW--RSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVR--CVA 575
                |.|:..:|..|  |...:|:..:|..|...|.|..|:||        :.:|.:..:  |..
Zfish   485 ----ICLSMCIFTFWFFRDIQNTRTTIHKNLCCSLFMAQFIFL--------IGINKSAHKWFCSL 537

  Fly   576 LGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIV-AWLLPLVPTLLVALIDPD 639
            :...:.|..|..|:||.|..   ...|:.|:|:.....::.:.... .:..|.|...:.|.:...
Zfish   538 IAGLLHYFFLAAFAWMCIEG---IHLYLIVVGVIYNKGFLHRNFYAFGYGSPAVVVAISATLGYK 599

  Fly   640 SY-VPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYSI-SHSLSQSIHKNEKK 702
            .| ..|...|||:.        ..|:..:.|..||.:.||:.|..:.|.: .|:..:....:..:
Zfish   600 YYGTSSVCWLSTEN--------NFIWSFIGPAILIILVNLLAFAVIIYKVYRHTAVKKPEISHYE 656

  Fly   703 MVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRL 765
            .:....|.:|.|.|:||:||.||:...:......:|||......||..:||:..:|   :||:
Zfish   657 NIRSCARGAIALLFVLGVTWAFGVMYILYETTLTAYLFTFANVFQGMFIFIFLCVL---SRRI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	14/47 (30%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	59/256 (23%)
adgrl4	NP_998532.2	EGF_CA	34..56	CDD:304395	4/21 (19%)
		EGF_CA	60..93	CDD:238011	8/32 (25%)
		EGF_CA	110..143	CDD:214542	8/37 (22%)
		GAIN	188..386	CDD:293098	33/210 (16%)
		GPS	416..457	CDD:280071	16/49 (33%)
		7tm_4	469..705	CDD:304433	61/267 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4884
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860