DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and mthl1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	160/749 - (21%)
Similarity:	251/749 - (33%)	Gaps:	265/749 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 WDPVVCL----RRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPAD 188
            |.|:|.|    |.|..|..|       ...|:....|..|..:.:.|.|    ||.||.|::
  Fly    82 WLPMVYLVQQQRFFEPHGAS-------PRFLKFLPNTRPTCRKDQTTEI----FRSRGANVM--- 132

  Fly   189 VHMTGQMF---GALMQQDKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDAL 250
            :...|.::   .|||.|..|..|..::..||          |..|..:||    |...:...:.|
  Fly   133 LFPNGTLYVRERALMVQPSDYCVDWEVAVVC----------LNDSQPINA----LEDPDYAANPL 183

  Fly   251 PEQLVPKDR------CGKVVAKPT-------SDEAETATTGVETYNFSDIGVQALITGNISVFFA 302
            .:|..||..      |||..:..|       ....:.|..|:...:      ..|..|:....:.
  Fly   184 VQQEPPKASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRLS------PQLPEGSYQTSYG 242

  Fly   303 NPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRG 367
            .|:|.:..|   :|..||                                       |:..|
  Fly   243 LPDCGQPGG---YSIAGD---------------------------------------WQDAK--- 262

  Fly   368 ATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFS 432
                                                 |..|...|.||    ::||        |
  Fly   263 -------------------------------------LDRNTAMLQLP----HKNL--------S 278

  Fly   433 IGSGCGYWNYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLG---EEILIT 494
            .|..|    .|....||          :..||.|  .||  |:...|.......:|   |:....
  Fly   279 AGQYC----LEHTQREG----------EVKIIAC--QHL--FSSAAGAGIHDGSIGGTIEQANGQ 325

  Fly   495 PINEKVLD---IISIVGCSLSLLGILGIFLTA---ALFKSWRSQASTKVLLHLCLAMCLQMMLF- 552
            .:.:.||.   ::|||..|.:|  :.|..|.|   ||  .||.|        :|...||   ||
  Fly   326 NLQKAVLTGGILVSIVFLSATL--VAGFLLPAVHHAL--HWRCQ--------ICYVTCL---LFG 375

  Fly   553 -VFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAF---LQFQRYVTVIGIERPP- 612
             :.|..:::|.:|  ...:..|..|...||:..|..|.|:..:.|   ..|:.:       ||.
  Fly   376 KILLAIEELSSSL--QPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDF-------RPSS 431

  Fly   613 ---------RYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICY-------PSGYG 661
                     ||:.  ::.||..||:.|.:.|.:|   .:|....|....|..|       .|.:.
  Fly   432 LERNQEALRRYLY--SLYAWGGPLLITFVAACVD---QLPETTLLRPGFGQLYCWFDNRNLSIFA 491

  Fly   662 LIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNE--KKMVVKQI--RLSIMLFFLLGLTW 722
            ..:|   |:.|:...|:.:||    |.:|.|:..:.|.:  |....|..  |:.:.|..::|:||
  Fly   492 YFYG---PIGLLLCANIALFV----STTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVVVMGVTW 549

  Fly   723 IFGIFAFMQAGVAFSYLFC-ITATMQGFVMFIYFVLLDSTNRRLWVG---LICPTKMELDVQKRT 783
            |..|.:::..|....:.|. :...:||  :||:.|:  ....::|..   :.|| ::..|:...|
  Fly   550 IADILSWLVGGPHGVWFFTDLINALQG--VFIFIVV--GCQPQVWTACRRIFCP-RLRHDITNTT 609

  Fly   784 ------------------TEL-QSMTTSSTNYNS 798
                              ||: |:.||::|..|:
  Fly   610 NGVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNT 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	9/37 (24%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	71/282 (25%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	71/287 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740