DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgrg1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001018317.1	Gene:	adgrg1 / 324948	ZFINID:	ZDB-GENE-030131-3671	Length:	648	Species:	Danio rerio

Alignment Length:	756	Identity:	157/756 - (20%)
Similarity:	263/756 - (34%)	Gaps:	250/756 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VTRECRVKDNRANWESTEH---------WDPVVCLR----RFREHTISGDLNSLHDDVLEGRRRT 160
            :|.:| .:.:....:|..|         |:|::.|.    ..:.||:      ...:.|:|...|
Zfish    72 ITAKC-TQSSSIQLDSNPHQNQSHFCVFWEPLLDLLIVEVNGKNHTL------CKPNGLQGTCCT 129

  Fly   161 NDTQGRRE---MTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSC 222
            :.:||.::   |.||:....:   |:::..|:.......||.:.              ||| ..|
Zfish   130 DLSQGVQDNAHMYGIVNGSVK---GDIITGDLKGNYIFDGAHIN--------------CKE-KFC 176

  Fly   223 DSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDI 287
            |...|: ....|....::.:|.:           |.|.....|:.|..|.:...||   :||:
Zfish   177 DEARLK-PRGANMIEEVVMRFNA-----------KGRVDLPCAQGTVIEMDEEFTG---HNFT-- 224

  Fly   288 GVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETA 352
                                       ..||             ||:           ::|...:
Zfish   225 ---------------------------VPAP-------------RFV-----------DANTIPS 238

  Fly   353 AFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFL 417
            .::|.:| |.| ||..:.::...|.:..||       .|.|....:...|.||.
Zfish   239 VYIPSSL-RSV-SRRKSKVVCTYYKNKTLF-------ERGPSKSALLDDIVGLS----------- 283

  Fly   418 LRNENLRN---------------PDSKAFSIGSG-CGYW-----NYETWSTEGVSTESSSDLLKD 461
            :.||.:||               |||      || |..|     |...|..:|..|..    :.:
Zfish   284 VENETIRNLIEPVKIRFHHRPFAPDS------SGRCVSWDTKQDNEVNWKDDGCDTVK----INE 338

  Fly   462 AIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALF 526
            ...|||.||||.||.||....::         |..:.|.|..|:.|||::||:..|.:|..  |.
Zfish   339 EQTECHCNHLTYFAILVQVEQKS---------TVRHLKALTFITAVGCAVSLVSCLVLFYW--LC 392

  Fly   527 KSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVN-GNTVRCVALGAAMQYSILVLFSW 590
            |..|.:.:...|:|..|.:.:.::...|:.|     .::.| .|...|...|:.:.|.:|....|
Zfish   393 KRRRGKKNQISLVHRGLVVAIFLLCLFFILT-----GILANVANETVCQLTGSLLHYGLLSTLCW 452

  Fly   591 MLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLV----PTLLVALI--DPDSYVPSAAQLS 649
            |   |...|..::.|       |.:..:.:..|:..|:    |.|||:::  ..|.|.....:.|
Zfish   453 M---AMEVFHTFLLV-------RKVFNSPLPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPS 507

  Fly   650 TDTG----ICY--PSGYGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQI 708
            .|..    :|:  ......:...::.:.|:.|......|.:|                 :||::|
Zfish   508 DDVNNPYRMCWMTEGDKSQLAHYIINIGLLAVVVSSGLVMLF-----------------LVVREI 555

  Fly   709 R------------LSIM-LFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDS 760
            |            |||. |..|.|.||..|...|........:||||..::|||.:.:.:..|:.
Zfish   556 RNRPDWKKIHVAFLSIWGLTCLYGTTWALGFLDFGPFSEVTLFLFCIINSLQGFFLMLRYYALER 620

  Fly   761 TNRRLWVGLICPTKMELDVQKRTTELQSMTTSSTNYNSRSH 801
            ..::             ||        |.:..|::.:|:.|
Zfish   621 MKKK-------------DV--------SSSDGSSSGSSKQH 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/42 (31%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	64/275 (23%)
adgrg1	NP_001018317.1	GPS	312..354	CDD:280071	15/45 (33%)
adgrg1	NP_001018317.1	7tm_4	369..611	CDD:304433	65/275 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910