DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrl3

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_011247763.1	Gene:	Adgrl3 / 319387	MGIID:	2441950	Length:	1586	Species:	Mus musculus

Alignment Length:	690	Identity:	146/690 - (21%)
Similarity:	257/690 - (37%)	Gaps:	200/690 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 REHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQ 202
            |.|..:||:             |...:...::.|::....|    ||.|.......:....|.::
Mouse   648 RNHLNAGDI-------------TYSVRAMDQLVGLLDVQLR----NLTPGGKDSAARSLNKLQKR 695

  Fly   203 DKDATVSVD-LVSVCKEIMSCDS----KVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGK 262
            ::.....|. :|.....::...:    :.|..|.||.|...||...|.....|.:.|:..|
Mouse   696 ERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTD---- 756

  Fly   263 VVAKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSAS 327
             :.:..:|                         ||.:
Mouse   757 -IVRENTD-------------------------NIQL---------------------------- 767

  Fly   328 GFWYRFIRFSEDLAKVKEESNLETAAFLPENL------------WRQVKSRGATYLIFKVYAHDA 380
                       ::|::..|.|||...| |||:            .:|....|...:.|.:|.:..
Mouse   768 -----------EVARLSTEGNLEDLKF-PENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLG 820

  Fly   381 LFVET------------SLQRTRKPRSKVISISIPGLRSN--YLSLPLPFLLRN-----ENLRNP 426
            .::.|            |...:....|.||:.:|....||  ||:.|:.|.:::     ||. ||
Mouse   821 PYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENF-NP 884

  Fly   427 DSKAFSIGSGCGYWNYET------WSTEG---VSTESSSDLLKDAIIECHTNHLTQFAFLVGG-S 481
            :         |.:|:|..      |||:|   ::|..:.       ..|..||||.||.|:.. .
Mouse   885 N---------CSFWSYSKRTMTGYWSTQGCRLLTTNKTH-------TTCSCNHLTNFAVLMAHVE 933

  Fly   482 YRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMC 546
            .:.:|        .:::.:||:|:.||..|||:.:|....|...|:..:|..:| :..:||:::.
Mouse   934 VKHSD--------AVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNT-IHKNLCISLF 989

  Fly   547 LQMMLFVF-LNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQ-FQRYVTVIGI- 608
            :..:||:. :|..|         ..:.|....|.:.:..|..|:||    ||: .|.|:.::.:
Mouse   990 VAELLFLIGINRTD---------QPIACAVFAALLHFFFLAAFTWM----FLEGVQLYIMLVEVF 1041

  Fly   609 --ERPPR-YILKAAIVAWLLPLVPTLLVALIDPDSY-VPSAAQLSTDTGICYPSGYGLIFGVVLP 669
              |...| |..   :|.:.:|.:...:.|.:|..|| ......|..||       | .|:..:.|
Mouse  1042 ESEHSRRKYFY---LVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDT-------Y-FIWSFIGP 1095

  Fly   670 VTLITVCNLVIFVYVFYSISHSLS---------QSIHKNEKKMVVKQ-IRLSIMLFFLLGLTWIF 724
            .|||.:.|::......|.:.|..:         .:|:..:.:..:|. :..:|.|..||||||.|
Mouse  1096 ATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAF 1160

  Fly   725 GIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRR 764
            |:....::.|..:|||.|..::||..:||:..:|....|:
Mouse  1161 GLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRK 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/46 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	69/266 (26%)
Adgrl3	XP_011247763.1	Gal_Lectin	111..191	CDD:366935
		OLF	205..461	CDD:128580
		HormR	563..627	CDD:214468
		GAIN	636..856	CDD:374574	46/294 (16%)
		GPS	882..934	CDD:197639	18/68 (26%)
		7tmB2_Latrophilin-3	942..1208	CDD:320671	73/284 (26%)
		TM helix 1	945..969	CDD:320671	10/23 (43%)
		TM helix 2	978..999	CDD:320671	5/21 (24%)
		TM helix 3	1009..1031	CDD:320671	7/25 (28%)
		TM helix 4	1050..1066	CDD:320671	3/18 (17%)
		TM helix 5	1085..1108	CDD:320671	9/30 (30%)
		TM helix 6	1141..1166	CDD:320671	11/24 (46%)
		TM helix 7	1170..1195	CDD:320671	9/24 (38%)
		Latrophilin	1208..1586	CDD:367050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810