DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11318 and Adgre1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	196/938 - (20%)
Similarity:	316/938 - (33%)	Gaps:	276/938 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NWCAGLFVVLALVSPIYSACPKENQMCLRNGTFQYCDGEERNSS-DELMQTHLVYCTSMF----- 62
            :|..|        ||.:..|...:: ||   |...|   .:||: ...:.::...|.|.|
  Rat   120 SWILG--------SPGHFLCTDVDE-CL---TIGIC---PKNSNCSNSVGSYSCTCQSGFVSNGS 169

  Fly    63 -CEPEEFQHDYITRNHDQTPHQNKWKRARIGERATLHDV-----CLLRNGMP----------VTR 111
             ||.|:   :.:|||             ...|.||.|:.     |....|:.          :..
  Rat   170 TCEDED---ECVTRN-------------ACPEHATCHNTLGSYYCTCNEGLEFSGGGPMFQGLEE 218

  Fly   112 ECRVKDNRANWESTEHWDPVVCLR------------------RFREHTISGDLNSLH--DDVLEG 156
            .|...| ..:..||......:|:.                  :...|...|:...:.  ||:...
  Rat   219 SCEDVD-ECSRNSTLCGPSFICINTLGSYSCSCPAGFSLSTFQIPGHPADGNCTDIDECDDICPS 282

  Fly   157 RRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMS 221
            .....:|.|....|             ..|......||    |...|::.|        |::|..
  Rat   283 NSSCTNTLGSYFCT-------------CHPGFASSNGQ----LNFTDQEVT--------CEDIDE 322

  Fly   222 CDSKVLRLSAQLNATN-------SLLSQFESYMDALPEQLVPKDRCGKVVAK------PTSDEAE 273
            |.....|.....:.||       |.|..|.  ||....|......|.::..|      |.|::.|
  Rat   323 CTQDPFRCGRNSSCTNVPGSYNCSCLPDFR--MDPGGSQAHGNFTCKRIPFKCKEDLIPKSEQIE 385

  Fly   274 TATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSAS--------GFW 330
            ....| :..|.........:....::.  :..|:.      .|||...:..:.|        ..|
  Rat   386 QCQAG-QGRNLDYTSFCTFVNATFTIL--DNTCEN------KSAPVSLQSAATSVSLMLEQASTW 441

  Fly   331 YRFIRFSEDLAKVKEESNLET-----------AAFL---------------------------PE 357
            :.|.|        :|.|.|.|           ||.|                           .|
  Rat   442 FEFSR--------EETSTLGTILLETVESTMLAALLTPSGNASQTIRTEYLEIESKVINEECNEE 498

  Fly   358 NLWRQVKSRG-----ATYLI------------FKVYAH-----DALFVETSLQRTRKPR--SKVI 398
            |:...:|:||     ..::|            |..:||     |..|.|.. |.:.|.|  |.|:
  Rat   499 NVSINLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMDSVLDERFFEDG-QASWKLRMNSHVV 562

  Fly   399 SISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNYET----WSTEGVSTESSSDLL 459
            ..::.|.|....|.|:.:.|::...:....::.     |..||.:.    |:..|..|..:|
  Rat   563 GGTVTGERKEDFSKPIVYTLQHIQPKQKSERSI-----CVSWNTDVEDGRWTPSGCETVEAS--- 619

  Fly   460 KDAIIECHT----NHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIF 520
                 |.||    |.:|..|.::..       ||..:     |..|.|||.||..:||:.:.
  Rat   620 -----ETHTVCSCNRMTNLAIIMAS-------GELTM-----EFSLYIISYVGTVISLVCLA--- 664

  Fly   521 LTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSIL 585
            |..|.|..:|:..:....|||.|.:||.:...:||...|.::      |...|..:...:.|..|
  Rat   665 LAIATFLLFRAVQNHNTYLHLHLCVCLFLAKILFLTGIDKTD------NQTACAIIAGFLHYLFL 723

  Fly   586 VLFSWMLIIAFLQF--------QRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSY- 641
            ..|.|||:.|.:.|        ..|.:...|:     :|......:.||:|..::.|.:.|..|
  Rat   724 ACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIK-----MLHLCAFGYGLPVVVVIISATVHPWGYG 783

  Fly   642 VPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVK 706
            :.:...|:|:|        |.|:..:.||.:|...|..:..:..:.:...|. |::....|:  |
  Rat   784 MHNRCWLNTET--------GFIWSFLGPVCMIITINSALLAWTLWVLRQKLC-SVNSEVSKL--K 837

  Fly   707 QIRL----SIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWV 767
            ..||    :|...|:||.:|:.|||.........:|||....::||..:|:...||:...|..:.
  Rat   838 DTRLLTFKAIAQIFILGCSWVLGIFQIGPLASIMAYLFTTINSLQGAFIFLIHCLLNRQVRDEYR 902

  Fly   768 GLICPTKMELDVQKRTTE--LQSMTTSS 793
            .|: ..|.:|....:|:.  |.||.::|
  Rat   903 KLL-TRKTDLSSHSQTSGILLSSMPSTS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/45 (27%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	68/262 (26%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542	9/45 (20%)
		EGF_CA	173..>203	CDD:214542	9/45 (20%)
		EGF_CA	222..255	CDD:214542	4/33 (12%)
		cEGF	245..275	CDD:289433	2/29 (7%)
		EGF_CA	272..>301	CDD:214542	6/41 (15%)
		EGF_CA	319..359	CDD:284955	10/41 (24%)
		Cell attachment site. /evidence=ECO:0000255	507..509		1/1 (100%)
		GPS	592..641	CDD:197639	13/68 (19%)
		7tm_2	646..886	CDD:278432	68/264 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810