DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	175/793 - (22%)
Similarity:	297/793 - (37%)	Gaps:	213/793 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EPEEFQHDYITRNHDQTPHQNKWKRARIGERATLHDVCLLRNGMPVTRECRVKDNRANWESTEHW 128
            :||.|:...|:.:..:.|..||                   .|..:.|.|...      |::..|
  Rat   531 DPEGFKWTAISPSVYKQPCPNK-------------------PGFFMMRTCLCN------ETSTFW 570

  Fly   129 DPVVCLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGR-REMTGIMRNMFRQRGGNLLPADVHMT 192
            .|:                    |.....|::|:.... .::||        .|.||..|:::..
  Rat   571 GPI--------------------DASNCSRQSNEVANEILDLTG--------DGQNLTSANINSI 607

  Fly   193 GQMFGALMQQDK--DATVSVDLVSVCKEIM-SCDSKVLRLSAQLNATNSLLSQFESYMDALPEQL 254
            .:....::.:::  |.|:...|:::...|: |.||.:|..|.:...|          :|.|..::
  Rat   608 VEQVKRIVNKEENIDRTLGSTLMNIFSNILSSSDSNLLESSTEALKT----------IDELAFKI 662

  Fly   255 VPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALITG-----NISVFFANPECDRITGLAI 314
                           |...|....:||.|.: :||.:|:.|     |.|:           ||.
  Rat   663 ---------------DLNSTPHVNIETQNLA-LGVSSLMPGTNAPSNFSI-----------GLP- 699

  Fly   315 FSAPGDQRKTSASGFWYRFIRFSED-LAKVKEESNLETAAFLPENLWRQVKS------RGATYLI 372
                    ..:.|.|...|.....| ||.|          .||.||...:..      |.|.:..
  Rat   700 --------SNNDSYFQMDFENGQADPLASV----------ILPPNLLENLSPEDSILVRRAQFTF 746

  Fly   373 FKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLL---RNENLRNPDSKAFSIG 434
            |.   ...||.:...|| :...|.|::.||..:....|..|:...:   |.:.:..|.
  Rat   747 FN---KTGLFQDVGSQR-KILVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHQPI------- 800

  Fly   435 SGCGYW------NYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILI 493
              |.:|      ::..|:|.|....|.||..:..   |..||.|.|..|:.....|:.:...
  Rat   801 --CAFWDLNQNKSFGGWNTSGCVAHSDSDAGETI---CLCNHFTHFGVLMDLPRSASQIDGR--- 857

  Fly   494 TPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTD 558
               |.|||..|:.:||.:|.:......||...|:..|....:|:|::|..|:       :|||..
  Rat   858 ---NTKVLTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSSAL-------LFLNLI 912

  Fly   559 DVSEALVVN-GNTVRCVALGAAMQYSILVLFSWM------LIIAFLQ-FQRYVTVIGIERPPRYI 615
            .:.:..:.: |....|.|:.|.:.:.:|..|:||      :.||.:: |..|:        .|||
  Rat   913 FLLDGWITSFGVAGLCTAVAALLHFFLLATFTWMGLEAIHMYIALVKVFNTYI--------HRYI 969

  Fly   616 LKAAIVAWLLP--LVPTLLVALIDPDSYVPSAAQLSTDTGICY---P-------SGYGLIFGVVL 668
            ||..|:.|.||  :|..:||:....:.|...:.....|...|:   |       :||   ||::.
  Rat   970 LKFCIIGWGLPALVVSIILVSRKQNEVYGKESYGKDQDDEFCWIQDPVVFYVSCAGY---FGIMF 1031

  Fly   669 PVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAG 733
                  ..|:.:|:.|...|.....:..::..::.|::.:|..:.|.||||:||.|..||:....
  Rat  1032 ------FLNVAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLN 1090

  Fly   734 VAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMEL----DVQKRTTEL-------- 786
            :.|.|||.|..::||..:||:...:....::.|...:|..:..|    |..|..|.:
  Rat  1091 IPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNL 1155

  Fly   787 -QSMTTSSTNYNS 798
             :|:::||...||
  Rat  1156 GKSLSSSSIGSNS 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/43 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	72/269 (27%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001
		LamG	178..337	CDD:304605
		GPS	799..844	CDD:280071	14/56 (25%)
		7tm_4	861..1108	CDD:304433	72/270 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6879
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910