DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11318 and Adgrg7

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001100568.1	Gene:	Adgrg7 / 304014	RGDID:	1307217	Length:	785	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	175/817 - (21%)
Similarity:	304/817 - (37%)	Gaps:	235/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QMCLRNGTFQ----YCDGEERNSSDELMQTHLVYCT-SMFCEPEEFQHDYITRNHDQTPHQNKWK 87
            |.|...||:|    .|..|.|.          :.|| :.|||...|.:             ..:.
  Rat    50 QFCRNGGTWQNGRCICTEEWRG----------LRCTIANFCENSTFMN-------------FTFG 91

  Fly    88 RARIGERATLHDVC---LLRNGMP-VTRECRVKDNRANWESTEHWDPVVCLRRFREHTISGDLN- 147
            :..:|.......:|   .:..|.| .||.|.|.                      |:.:...||
  Rat    92 KIPVGRYGPSFQICGPNTVNAGQPQATRLCGVS----------------------EYGVIEALNV 134

  Fly   148 -----SLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADV----HMTGQMFGALMQQD 203
                 ..:.::||  ::.||.....:.......:.......|...::    .:.||:|......:
  Rat   135 TIGNCDKNLEILE--KQINDISNNSQNISSDAQVLTTDASKLTAENITSATTVVGQIFNKTRNAN 197

  Fly   204 KDA-TVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKP 267
            .:| .|:|..||   :|:.....|.:.:|:.:.:||..:..|.
  Rat   198 SEAKKVAVTTVS---QILDASEDVFQKAAENDNSNSFSNLIEQ---------------------- 237

  Fly   268 TSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAI-FSAPGDQRKTSASGFWY 331
                       :|.|:|| :|.:|::..|:::...:...|  :|.:: ||.   |:.:|.|
  Rat   238 -----------MENYSFS-LGDEAVVEPNVAIQSVSRNSD--SGPSVLFSV---QKGSSDS---- 281

  Fly   332 RFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLI-------------FKVYAHDALFV 383
                      .|..|:::...|       .::|..|.|.|.             |.||.:..||.
  Rat   282 ----------LVSSETSINKTA-------DELKPDGQTELQILLNTGGNKNSCGFVVYQNHKLFQ 329

  Fly   384 ETSLQRTRKPRSKVIS--ISIPGLRSNYLSLPLPFLLRNENLRNP--DSKAFSIGS-GCGYWNY- 442
            ..:...|.....|:||  ::......|.:|:.:.|        ||  |.:.|.:.| .|.|||.
  Rat   330 SKTFTATSDFSQKIISSKVNASEQEQNNVSVKMVF--------NPTYDKREFQLYSYACVYWNIL 386

  Fly   443 -ETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVG--GSYRANDLGEEILITPINEKVLDII 504
             :.|.|.|.....::    ...:.|..||.|.||.|:.  ..|:             ..|.||::
  Rat   387 KKDWDTAGCQKSVNA----SGFLGCQCNHTTNFAVLMSFKKDYK-------------YPKSLDVL 434

  Fly   505 SIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVF--------LNTDD-- 559
            |.:||:||:.|:....|...|.:..|..:.|.||:.||::|.:..:||||        |.|.|
  Rat   435 SNIGCALSIAGLAITILFQILTRKIRKTSVTWVLVSLCISMLIFNLLFVFGIENSNKNLKTSDSN 499

  Fly   560 ---------VSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERP-PR- 613
                     :.|...:......|.|:.|.:.|.:|..|:|..:.|   .|.|..:|...:| ||
  Rat   500 INANPNENKIPETDTIETPNPSCTAIAALLHYFLLGTFTWNGLSA---TQLYFLLIRTMKPLPRH 561

  Fly   614 YILKAAIVAWLLPLVPT-----LLVALIDPDSY--------------VPSAAQLSTDTGICYPSG 659
            :|:..::|.|.:|.:..     ::.||....||              ||.....:...
  Rat   562 FIVIISLVGWGVPAIIVGVTIGIIYALSGNKSYWELDYRQEEICWLAVPKNNDFARSP------- 619

  Fly   660 YGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIF 724
              |::..::|||:|.:.|:.|||.:...:....:|::...:|...:|::..::.:..:.|:||||
  Rat   620 --LLWSFIMPVTIILITNIAIFVIITVKVLWKNNQNLTSTKKVSSLKKVLSTLSIAVVFGVTWIF 682

  Fly   725 GIFAFM----QAGVAFSYLFCITATMQGFVMFIYFVL 757
            . :|.:    ...:.|||:||:..|.||..:||.:.:
  Rat   683 A-YAMLINNDDIRIVFSYIFCLFNTTQGLQIFILYTV 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/39 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	75/293 (26%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:396408	13/43 (30%)
		7tmB2_GPR128	428..727	CDD:320385	78/304 (26%)
		TM helix 1	431..455	CDD:320385	9/23 (39%)
		TM helix 2	465..486	CDD:320385	10/20 (50%)
		TM helix 3	523..545	CDD:320385	7/24 (29%)
		TM helix 4	565..581	CDD:320385	3/15 (20%)
		TM helix 5	617..640	CDD:320385	7/31 (23%)
		TM helix 6	666..688	CDD:320385	6/22 (27%)
		TM helix 7	695..720	CDD:320385	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6879
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4709
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto97621
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960