Protein Alignment Mayo and Adgrg2

DIOPT Version :10

• Sequence 1: NP_651842.3
• Gene: Mayo / 43678
• FlyBaseID: FBgn0039818
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: NP_852031.1
• Gene: Adgrg2 / 266735
• RGDID: 628618
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 647
• Identity: 155/647 - (23%)
• Similarity: 260/647 - (40%)
• Gaps: 122/647 - (18%)

  Fly   229 LSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQ--- 290
            ||..|:...|.:....:...::||::|       .::.|..:      |.|.|.:..|:..|
  Rat   328 LSHTLSPVQSSIPSPTTAAPSVPEKVV-------AISTPPGE------TVVNTSSVPDLEAQVSQ 379

  Fly   291 ---ALITGNISVFFANPECDRITGL----AIFSAPGDQR---KTSASGFWYRFIRF-------SE 338
               ||..|::....|....:|::.|    ....||..||   ...|.|....|...       |.
  Rat   380 MEKALSLGSLEPNLAGEMVNRVSKLLHSPLALLAPLAQRLLKVVDAIGLQLNFSSTTISLTSPSL 444

  Fly   339 DLAKVK-EESNLETAAFL---PENLWRQVKSRG-------------------------ATYLIFK 374
            .||.:: ..||..|..|.   |.||...::::.                         |:.:.|.
  Rat   445 ALAVIRVNASNFNTTTFAAQDPANLQVSLEAQAPKNSIGAITLPSSLMSNLPASEVELASRVQFN 509

  Fly   375 VYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGY 439
            .:...|||.:.||:.. ...|.|||.|:..:....|:..:...|::.|....|     :...|.:
  Rat   510 FFETPALFQDPSLENL-SLISYVISSSVTNMTIKNLTRNVTVALKHINPSQDD-----LTVKCVF 568

  Fly   440 WNYET------WSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINE 498
            |:...      ||::|.|.:...  :.:.|..|  :|||.|..|:       ||....| .|...
  Rat   569 WDLNRNGGRGGWSSDGCSVKEKR--MNETICTC--SHLTSFGILL-------DLSRTSL-PPSQM 621

  Fly   499 KVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEA 563
            ..|..|:.:||.||.:.:....:|...|:..|....:|:|:.||.|:.|..::|:      :...
  Rat   622 MALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFL------LDSW 680

  Fly   564 LVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIG--IERPPRYILKAAIVAWLLP 626
            :.:......|:::...:.|.:||.|:||.:.||..:...|.|..  |.   :||||..||.|.:|
  Rat   681 IALYNARGFCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIR---KYILKFCIVGWGIP 742

  Fly   627 LVPTLLVALIDPDSY-VPSAAQL--STDTGICYPSGYGLIFGVVLPVT------LITVCNLVIFV 682
            .|...:|..|.||:| :.|..:.  .|....|:.:.     .||..:|      :|.:.|:.:|:
  Rat   743 AVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINS-----SVVFYITVVGYFCVIFLLNVSMFI 802

  Fly   683 YVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQ 747
            .|...:.....:.....::|..::.:|....|.||||:||.|..||:....:.|.|||.|..|:|
  Rat   803 VVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNLTFMYLFAIFNTLQ 867

  Fly   748 GFVMFIYFVLLDSTNRRLWVGLICPTKMEL-----------DVQKRTTELQSMTTSSTNYNS 798
            ||.:||::.......|:.|...:|..|:.|           :..|:.|..|.:::||.:..|
  Rat   868 GFFIFIFYCAAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQS 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mayo	NP_651842.3	7tmB2_Adhesion	498..766	CDD:320168	76/278 (27%)
		TM helix 1	500..525	CDD:320168	7/24 (29%)
		TM helix 2	535..557	CDD:320168	7/21 (33%)
		TM helix 3	574..600	CDD:320168	8/25 (32%)
		TM helix 4	615..635	CDD:320168	9/19 (47%)
		TM helix 5	659..688	CDD:320168	7/34 (21%)
		TM helix 6	704..730	CDD:320168	11/25 (44%)
		TM helix 7	734..759	CDD:320168	11/24 (46%)
Adgrg2	NP_852031.1	GPS	564..608	CDD:460350	12/47 (26%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	566..615		15/59 (25%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q8CJ12	604..615		4/17 (24%)
		7tmB2_GPR64	621..890	CDD:320560	77/282 (27%)
		TM helix 1	623..648	CDD:320560	7/24 (29%)
		TM helix 2	658..680	CDD:320560	7/27 (26%)
		TM helix 3	691..718	CDD:320560	8/26 (31%)
		TM helix 4	733..749	CDD:320560	6/15 (40%)
		TM helix 5	779..802	CDD:320560	5/22 (23%)
		TM helix 6	825..850	CDD:320560	11/24 (46%)
		TM helix 7	854..879	CDD:320560	11/24 (46%)