DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001074811.1	Gene:	Adgrd1 / 243277	MGIID:	3041203	Length:	903	Species:	Mus musculus

Alignment Length:	846	Identity:	181/846 - (21%)
Similarity:	309/846 - (36%)	Gaps:	233/846 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CEPEEFQHDYITRNH-DQT---PHQNKWKRARIGERATLHDVCLLRNGMPVTRECRVKDNRANWE 123
            |.||.....:..:.. |||   |:....:....|.:     ||  .:|...:.|...:||...|:
Mouse   132 CGPEGVTFSFFWKTQGDQTRPAPYAYGGQVVSDGFK-----VC--SSGGKGSVELYTRDNSMTWK 189

  Fly   124 ST-----EHWDPVVCLRRFREHT---ISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQR 180
            :|     .:|..|:...:.:|..   ::|.|:            |:|..|:...|
Mouse   190 ATFNPPGPYWTHVLFTWKSKEGLKVYVNGTLS------------TSDPSGKVSHT---------- 232

  Fly   181 GGNLLPADVHMTGQMFGALMQQDKD-ATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFE 244
                 ..|.|: ..:.|:...|.|. ...:.|...:.:..::.|...:..:|.: ..::|||
Mouse   233 -----YGDPHV-NLVIGSEQDQTKRYENGAFDEFIIWERALTPDEIKMYFTAAI-GKHALLS--- 287

  Fly   245 SYMDALP--EQLVPKDRCGKVVAKPTSD--------------------------EAETATTGVET 281
            |...|:|  ..::|.|....::...|.:                          ..|||....||
Mouse   288 STPPAMPTAHTVIPTDAYHPIITNLTEERKRFQRPGTVLRYLQNVSLRLPNKSLSEETALNLTET 352

  Fly   282 Y-------------------NFSDIGVQALI---TGNISVFFANPECD-RITGLA---------- 313
            :                   |...:|:...|   .|:||....:.|.. .:||.:
Mouse   353 FLRTVGEVLLLPSWTHESEDNAMTLGLVDTIDTVMGHISSNLQSREPHVTLTGSSSTAEFTVAKV 417

  Fly   314 ---IFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKV 375
               ..|||           .|||........::..|:       |....|..:.  |..|.....
Mouse   418 LPPALSAP-----------HYRFPAHGHSYIEIPREA-------LHSQAWTTIV--GLLYHTMHY 462

  Fly   376 YAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSL---PLPFLLRN--------ENLRNP-DS 428
            |..:.....|.:......|..::|::     |:.:||   |.|.|.:|        .:||:. ..
Mouse   463 YLKNIHPTSTEIPEAVNCRDCLLSVA-----SHLISLEVSPPPTLSQNLSGSPLITVHLRHKLTQ 522

  Fly   429 KAFSIGSG--------CGYWNYET----WSTEGVS-TESSSDLLKDAIIECHTNHLTQFAFLVGG 480
            |.:|..:.        |.:.|:.:    ||::|.: ||.:   |..::  ||..|||.||.|
Mouse   523 KQYSDATNESNRLFLYCAFLNFSSGEGVWSSQGCALTEGN---LTYSV--CHCTHLTNFAIL--- 579

  Fly   481 SYRANDLGEEILITPI-----NEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLH 540
                      :.:.|:     ::..|..||.||||||:|.:....:|.|:..|..:..:.:..:|
Mouse   580 ----------MQVVPLKLTHGHQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQRYHIH 634

  Fly   541 LCLAMCL---QMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRY 602
            ..|:..:   |::|.:..:.:.         .||.|..|...:.|..|..|:|||:.....:...
Mouse   635 ANLSFAVLVAQVLLLISFSMEP---------GTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMV 690

  Fly   603 VTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPS-GYGLIFGV 666
            :.|.|.|.........  :.|..||:..::......|||..|.:        |:.: |.|.|:..
Mouse   691 IKVFGSEDSKHLYYYG--IGWGCPLLICIISISSSMDSYGTSDS--------CWLALGSGAIWAF 745

  Fly   667 VLPVTLITVCNLVIFVYVFYSISHSLSQS--IHKNEK--KMVVKQIRLSIMLFFLLGLTWIFGIF 727
            |.|..|:.|.|:||.|.|...|||..:.|  ||.:..  |:..|.:   .:|..:||.:|:||:.
Mouse   746 VGPALLVIVVNIVILVAVTRVISHISTDSYKIHGDPSAFKLTAKAV---AVLLPILGTSWVFGVL 807

  Fly   728 AFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMELDVQKRTTELQSMTTS 792
            |.....:.|.|:|.|..::||..:|::..||:|..|..:              |..|::.|:|:|
Mouse   808 AVSDRALVFQYMFAILNSLQGLFIFLFHCLLNSEVRAAF--------------KHKTKVWSLTSS 858

  Fly   793 S 793
            |
Mouse   859 S 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/42 (31%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	71/257 (28%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121	21/127 (17%)
		GPS	539..579	CDD:280071	15/44 (34%)
		Stachel. /evidence=ECO:0000250\|UniProtKB:Q6QNK2	575..583		3/20 (15%)
		7tm_4	595..831	CDD:304433	71/257 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810