DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrg2

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_006528869.1	Gene:	Adgrg2 / 237175	MGIID:	2446854	Length:	1092	Species:	Mus musculus

Alignment Length:	655	Identity:	161/655 - (24%)
Similarity:	265/655 - (40%)	Gaps:	131/655 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQ--- 290
            ||..|:...|.:....:...::|.:||       .::.|..:      |.|.|...||:..|
Mouse   400 LSHTLSPVQSSIPSPTTPAPSVPTELV-------TISTPPGE------TVVNTSTVSDLEAQVSQ 451

  Fly   291 ---ALITGNISVFFANPECDRITGL----AIFSAPGDQR---KTSASGFWYRF------------ 333
               ||..|::....|....:|::.|    ....||..||   ...|.|....|
Mouse   452 MEKALSLGSLEPNLAGEMVNRVSKLLHSPPALLAPLAQRLLKVVDAIGLQLNFSSTTISLTSPSL 516

  Fly   334 ----IR-----FSEDLAKVKEESNLET------------AAFLPENLWRQVKSRG---ATYLIFK 374
                ||     |:......::.:||:.            |..||.:|...:.:..   |:.:.|.
Mouse   517 ALAVIRVNASNFNTTTFAAQDPTNLQVSLETPPPENSIGAITLPSSLMNNLPANDVELASRIQFN 581

  Fly   375 VYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGY 439
            .:...|||.:.||:.... .|.|||.|:..:....|:..:...|::.| .:||.....    |.:
Mouse   582 FFETPALFQDPSLENLTL-ISYVISSSVTNMTIKNLTRNVTVALKHIN-PSPDDLTVK----CVF 640

  Fly   440 WNY---ET----------WSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEI 491
            |:.   :|          ||::|.|.:...  :.:.|..|  :|||.|..|:       ||....
Mouse   641 WDLGRNDTALVPTGGKGGWSSDGCSVKDKR--MNETICTC--SHLTSFGILL-------DLSRTS 694

  Fly   492 LITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLN 556
            | .|.....|..|:.:||.||.:.:....:|...|:..|....:|:|:.||.|:.|..::|:.
Mouse   695 L-PPSQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLL-- 756

  Fly   557 TDDVSEALVVNGNTVR-CVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIG--IERPPRYILKA 618
                 ::.:...||.. |:|:...:.|.:||.|:||.:.||..:...|.|..  |.   :||||.
Mouse   757 -----DSWIALYNTRGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIR---KYILKF 813

  Fly   619 AIVAWLLPLVPTLLVALIDPDSY-VPSAAQL--STDTGICYPSGYGLIFGVVLPVT------LIT 674
            .||.|.:|.|...:|..|.||:| :.|..:.  .|....|:.:.     .||..:|      :|.
Mouse   814 CIVGWGIPAVVVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINS-----NVVFYITVVGYFCVIF 873

  Fly   675 VCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYL 739
            :.|:.:|:.|...:.....:.....::|..::.:|....|.||||:||.|..||:....|.|.||
Mouse   874 LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYL 938

  Fly   740 FCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMEL-----------DVQKRTTELQSMTTSS 793
            |.|..|:|||.:||::.......|:.|...:|..|:.|           :..|:.|..|.:::||
Mouse   939 FAIFNTLQGFFIFIFYCAAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSS 1003

  Fly   794 TNYNS 798
            .:..|
Mouse  1004 NSLQS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/50 (24%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	76/261 (29%)
Adgrg2	XP_006528869.1	Atrophin-1	<288..>423	CDD:367360	4/22 (18%)
		PRK14948	<368..559	CDD:237862	33/171 (19%)
		GPS	637..687	CDD:366827	13/57 (23%)
		7tmB2_GPR64	700..969	CDD:320560	81/283 (29%)
		TM helix 1	703..727	CDD:320560	7/23 (30%)
		TM helix 2	737..758	CDD:320560	7/27 (26%)
		TM helix 3	770..792	CDD:320560	7/21 (33%)
		TM helix 4	812..828	CDD:320560	6/15 (40%)
		TM helix 5	858..881	CDD:320560	5/22 (23%)
		TM helix 6	904..929	CDD:320560	11/24 (46%)
		TM helix 7	933..958	CDD:320560	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4857
Isobase	1	0.950	-	0	Normalized mean entropy	S7779
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910