DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrg4

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001349814.1	Gene:	Adgrg4 / 236798	MGIID:	2685213	Length:	3025	Species:	Mus musculus

Alignment Length:	761	Identity:	175/761 - (22%)
Similarity:	302/761 - (39%)	Gaps:	155/761 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DQTPHQNK--WKRARIGERATLHDVCLLRNGMPVTREC--RVKDNRANWESTEHWDPVVCLRRFR 138
            |:||.:.|  :|........|..:.|:.......||.|  .::..:..||..          |.:
Mouse  2292 DETPSKYKGTYKWPLTDPTETAQERCIKNENRNATRICSISIQTGKCQWEKP----------RLK 2346

  Fly   139 EHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQD 203
            :..:   |..|.|.:::....|...:...::...:.|:..:..    |.|              :
Mouse  2347 QCKL---LQGLPDKIVDLANITISDENADDVAEHILNLVNESP----PLD--------------E 2390

  Fly   204 KDATVSVDLVSVCKEIMSCDSKVLRLS----AQLNATNSLLSQFESYMDALPEQLVPKDRCGKVV 264
            ::..:   :||...:|.:||...:.|:    ..||......|...|.:..:..:::   |..:.|
Mouse  2391 EETKI---IVSKVADISNCDEISINLTQIILQILNTVTEKQSDSASNLPPVSNEIL---RIIERV 2449

  Fly   265 AKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGF 329
            .........||...|.....:.:.|.....|   :.|:....:.:....||......||..||
Mouse  2450 GHKMEFAGRTANLTVAKLALAVLRVDHKFEG---MAFSIQSSEEVIAPQIFLGDIPLRKALAS-- 2509

  Fly   330 WYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPR 394
                                   .:||::|..:|...|...::|..:...:||...::  |.:..
Mouse  2510 -----------------------IYLPKSLREKVPLDGLQTILFNFFGQTSLFKAKTI--TSELM 2549

  Fly   395 SKVISISIPGLRSNYLSLPLPFLLRN-ENLRNPDSKAFSIGSGCGYWNYET------WSTEGVST 452
            :.|:|.||.......|:.|:..:|:: :...|.|...      |.:|:::|      |:..|..
Mouse  2550 TYVVSASISNTSIQNLADPVIIILKHIQGDWNYDQVY------CAFWDFDTNNGLGGWNPSGCK- 2607

  Fly   453 ESSSDLLKDAIIE---CHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLL 514
                  ||::.|.   |..||||.|..|:       ||... .:..:||::|.||:..||.:|.:
Mouse  2608 ------LKESNINYTICQCNHLTHFGVLM-------DLSRS-TVDAVNERILVIITYTGCGISSI 2658

  Fly   515 GILGI-FLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGA 578
             .||| .:|...|...|....:|:|::||.|:.:..:.|:      |:..|........|:....
Mouse  2659 -FLGIAMVTYIAFHKLRKDYPSKILINLCTALLMLNLAFL------VNSWLTSFQKVGLCITAAV 2716

  Fly   579 AMQYSILVLFSWM------LIIAFLQ-FQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALI 636
            |:.|.:||..:||      :..|.:: |..|:        |.||||..:..|.:|.:...::..:
Mouse  2717 ALHYFLLVSLTWMGLEAVHMYFALVKVFNTYI--------PNYILKFCLAGWGIPAITVAIILSV 2773

  Fly   637 DPDSYVPSAAQLSTDTGICYPSGYGLIF-GVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNE 700
            ..|.|    ..||..|..|:.....:.: .||....||.:.||.:|..|...::...||| .|..
Mouse  2774 RKDLY----GTLSPTTPFCWIKDDHIFYISVVAYFCLIFLMNLSMFCTVLVQLTSVKSQS-QKTR 2833

  Fly   701 KKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRL 765
            |||::..::.:|.|.|||||||.|..||:....:.|.|||.|..|:|||::|:::.::..:.|..
Mouse  2834 KKMILNDLKGTISLTFLLGLTWGFAFFAWGPVRIFFLYLFAICNTLQGFLIFVFYCVMKESVREQ 2898

  Fly   766 W-VGLICP-TKME-----LDV---QKR----------TTELQSMTT 791
            | :.|.|. .::|     ::|   |||          |..|.|.||
Mouse  2899 WHMPLHCRWLRLENFAGWINVRHKQKRLKKNNESKLLTPSLMSTTT 2944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/46 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	78/258 (30%)
Adgrg4	NP_001349814.1	LamG	<54..162	CDD:328935
		DnaJ	<276..746	CDD:333066
		GPS	2587..2629	CDD:307782	14/48 (29%)
		7tmB2_GPR112	2642..2903	CDD:320663	83/280 (30%)
		TM helix 1	2644..2669	CDD:320663	10/25 (40%)
		TM helix 2	2679..2701	CDD:320663	7/27 (26%)
		TM helix 3	2712..2739	CDD:320663	6/26 (23%)
		TM helix 4	2754..2770	CDD:320663	3/15 (20%)
		TM helix 5	2793..2816	CDD:320663	6/22 (27%)
		TM helix 6	2838..2863	CDD:320663	12/24 (50%)
		TM helix 7	2867..2892	CDD:320663	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040