DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrf5

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_006524187.1	Gene:	Adgrf5 / 224792	MGIID:	2182928	Length:	1406	Species:	Mus musculus

Alignment Length:	759	Identity:	164/759 - (21%)
Similarity:	271/759 - (35%)	Gaps:	229/759 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDATVSV---DLVSVCKEIMSCDSKVLRL 229
            :.:|:..:..:..||.       :|.:..|...:::..|.:|.   .|:.|.|.::...::..:|
Mouse   745 QFSGVYGSPGQAIGGT-------VTYKCVGTQWKEESRACISAPINGLLQVAKALIKSPTQDQKL 802

  Fly   230 SAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALIT 294
            ...|...:....:.|..:.:.|..|      |.:::  ..|...|..|.|.:....||    |.|
Mouse   803 PTYLRDLSVSAGKEEQDIRSSPGSL------GAIIS--ILDLLSTVPTQVNSEMMRDI----LAT 855

  Fly   295 GNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPE-N 358
            .|:.:       |: :.|..:.....|:...:|.|.:...|||:.|     :....|..||.. |
Mouse   856 INVIL-------DK-SALNSWEKLLQQQSNQSSQFLHSVERFSQAL-----QLGDSTPPFLAHPN 907

  Fly   359 LWRQVKS----RGATYLIFKVYAHDALFVETSL----------QRTRKPRSKVISISIPGLRSNY 409
            :  |:||    ||..    ::|....:|.::.|          ....:|.|.:::::.|.|::
Mouse   908 V--QMKSMVIKRGHP----QIYQQQFIFKDSDLWGDVAIDECQLGNLQPDSSIVTVAFPTLKA-- 964

  Fly   410 LSLPLPFLLRNENLRNPDS--------------KAFSIG--------SG----CGYWNYET---- 444
                   :|..:..|...|              |.|.|.        ||    |.:||:..
Mouse   965 -------ILAQDVQRKTSSNSLVMTTTVSHNIVKPFRISMTFKNNHRSGGKPQCVFWNFSLANNT 1022

  Fly   445 --WSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIV 507
              |.:.|.|.|......:|.:. |..||||.|:.|:  |..:.|.|..:.|      :|||||.:
Mouse  1023 GGWDSSGCSVEDDGRDNRDRVF-CKCNHLTSFSILM--SPDSPDPGSLLKI------LLDIISYI 1078

  Fly   508 GCSLSLLGILGIFLTAALFKSWRS--QASTKVLLHLC---LAMCLQMMLFVFLNTDDVSEALVVN 567
            |...|::.:....:..|:.  |:|  :..|..:.|:|   :|.||.:....|:    |:.| :.:
Mouse  1079 GLGFSIVSLAACLVVEAMV--WKSVTKNRTSYMRHICIVNIAFCLLIADIWFI----VAGA-IHD 1136

  Fly   568 G----NTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLV 628
            |    |...|||....:.:..|.:|.|||.:..:.|.|.:
Mouse  1137 GRYPLNETACVAATFFIHFFYLSVFFWMLTLGLMLFYRLI------------------------- 1176

  Fly   629 PTLLVALIDPDSYVPSAAQLSTDTGICYPSGYG-------LIFGV-------------------- 666
                        ::...|..||...|.:..|||       :..||
Mouse  1177 ------------FILHDASKSTQKAIAFSLGYGCPLIISSITVGVTQPQEVYMRKNACWLNWEDT 1229

  Fly   667 ------VLPVTLITVCNLVIFVYVFYSISH-SLSQSIHKNEKKMVVKQIRLSI-MLFFLLGLTWI 723
                  .:|..:|.|.|:.|.|.|...|.. |:.....|.||..:. ||..|| :|..||||||.
Mouse  1230 RALLAFAIPALIIVVVNVSITVVVITKILRPSIGDKPGKQEKSSLF-QISKSIGVLTPLLGLTWG 1293

  Fly   724 FGIFAFMQ-AGVAFSYLFCITATMQGFVMFIYFVLLD-----------STNRRLW---------V 767
            ||:...:| :...|..:|.:....||..:.::..|.|           |.:|  |         :
Mouse  1294 FGLATVIQGSNAVFHIIFTLLNAFQGLFILLFGCLWDQKVQEALLHKFSLSR--WSSQHSKSTSI 1356

  Fly   768 GLICPT-KMELDVQKRTTEL----------QSMTTSSTNYNSRS 800
            |...|. .|...:.:|...|          ...||||:..||.|
Mouse  1357 GSSTPVFSMSSPISRRFNNLFGKTGTYNVSTPETTSSSLENSSS 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/43 (30%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	70/294 (24%)
Adgrf5	XP_006524187.1	IG	301..375	CDD:214652
		ig	535..608	CDD:365836
		GPS	1009..1056	CDD:366827	14/47 (30%)
		7tm_GPCRs	1070..1343	CDD:391938	73/323 (23%)
		TM helix 1	1071..1096	CDD:341315	7/24 (29%)
		TM helix 2	1111..1133	CDD:341315	7/25 (28%)
		TM helix 3	1147..1170	CDD:341315	7/22 (32%)
		TM helix 4	1190..1206	CDD:341315	4/15 (27%)
		TM helix 5	1228..1251	CDD:341315	5/22 (23%)
		TM helix 6	1275..1300	CDD:341315	13/25 (52%)
		TM helix 7	1305..1330	CDD:341315	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810