DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and ADGRF5

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_005248949.1	Gene:	ADGRF5 / 221395	HGNCID:	19030	Length:	1386	Species:	Homo sapiens

Alignment Length:	909	Identity:	179/909 - (19%)
Similarity:	325/909 - (35%)	Gaps:	230/909 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TFQYCDGEE-----RNSSDELMQT-HLVYCTSMFCEPEEFQHDYITRNHDQTPHQNKWK------ 87
            |.:|.||.|     :.|:.|...| |.::         .:::.|.....|...|....|
Human   559 TRRYLDGAESVLTVKTSTREWNGTYHCIF---------RYKNSYSIATKDVIVHPLPLKLNIMVD 614

  Fly    88 --RARIGERATLHDVCLLR-------------NGMPVTRECRVKD---------NRANW------ 122
              .|.:....:.|..|.:.             :.:|..:|...|.         :..:|
Human   615 PLEATVSCSGSHHIKCCIEEDGDYKVTFHTGSSSLPAAKEVNKKQVCYKHNFNASSVSWCSKTVD 679

  Fly   123 --------ESTEHWDPVVCLRRFREHTISGDLNSLHDDVL----EGR------RRTNDTQGRREM 169
                    .:...|.|.:.|     :.:.|:..:..|.|:    .|:      |.:|........
Human   680 VCCHFTNAANNSVWSPSMKL-----NLVPGENITCQDPVIGVGEPGKVIQKLCRFSNVPSSPESP 739

  Fly   170 TG------IMRNMFRQRGGNLLPADVHMTGQMFGALMQ---QD-------KDATVSVDLVSVCKE 218
            .|      .:.:.:.::..:.:.|.::...||..||::   ||       ||.::|:|...  .|
Human   740 IGGTITYKCVGSQWEEKRNDCISAPINSLLQMAKALIKSPSQDEMLPTYLKDLSISIDKAE--HE 802

  Fly   219 IMSCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLV------PKDRCGKVVAKPTSDEAETATT 277
            |.|....:..:...|:..:::.:|..|.|.......|      |.....||:.:..::::.....
Human   803 ISSSPGSLGAIINILDLLSTVPTQVNSEMMTHVLSTVNVILGKPVLNTWKVLQQQWTNQSSQLLH 867

  Fly   278 GVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGD--QRKTSASGF--WYRFIRFSE 338
            .||.::      |||.:|:......:....:::.:.|.|:..:  |::.....|  |...:....
Human   868 SVERFS------QALQSGDSPPLSFSQTNVQMSSMVIKSSHPETYQQRFVFPYFDLWGNVVIDKS 926

  Fly   339 DLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIP 403
            .|..::.:|::.|.|| |              .:..:.|.|       :|......|.|::.::
Human   927 YLENLQSDSSIVTMAF-P--------------TLQAILAQD-------IQENNFAESLVMTTTV- 968

  Fly   404 GLRSNYLSLP--LPFLLRNENLRNPDSKAFSIGSGCGYWNYET------WSTEGVSTESSSDLLK 460
               |:..::|  :....:|.:....::|       |.:||:..      |.:.|...|...
Human   969 ---SHNTTMPFRISMTFKNNSPSGGETK-------CVFWNFRLANNTGGWDSSGCYVEEGD---- 1019

  Fly   461 DAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEK-------VLDIISIVGCSLSLLGILG 518
            ...:.|..:|||.|:               ||::|.:..       :|||||.||...|:|.:..
Human  1020 GDNVTCICDHLTSFS---------------ILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAA 1069

  Fly   519 IFLTAALFKSWRS--QASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTV----RCVALG 577
            ..:..|:.  |:|  :..|..:.|.|:......:|..  ||..:..|.:.:...:    .|||..
Human  1070 CLVVEAVV--WKSVTKNRTSYMRHTCIVNIAASLLVA--NTWFIVVAAIQDNRYILCKTACVAAT 1130

  Fly   578 AAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYV 642
            ..:.:..|.:|.|||.:..:.|.|.|.:  :....|...||  :|:.|.....|.:::|...:..
Human  1131 FFIHFFYLSVFFWMLTLGLMLFYRLVFI--LHETSRSTQKA--IAFCLGYGCPLAISVITLGATQ 1191

  Fly   643 PSAAQLSTDTGICYPS--GYGLIFGVVLPVTLITVCNLVIFVYVFYSISH-SLSQSIHKNEKKMV 704
            |  .::.|...:|:.:  ....:....:|..:|.|.|:.|.:.|...|.. |:.....|.||..:
Human  1192 P--REVYTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILRPSIGDKPCKQEKSSL 1254

  Fly   705 VKQIRLSI-MLFFLLGLTWIFGI-FAFMQAGVAFSYLFCITATMQGFVMFIYFVLLD-------- 759
            . ||..|| :|..||||||.||: ..|....:.|..:|.|....||..:.::..|.|
Human  1255 F-QISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFILLFGCLWDLKVQEALL 1318

  Fly   760 ---STNRRLW---------VGLICPT-KMELDVQKRTTELQSMT----------TSSTNYNSRS 800
               |.:|  |         :|...|. .|...:.:|...|...|          |||:..||.|
Human  1319 NKFSLSR--WSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTGTYNVSTPEATSSSLENSSS 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	10/43 (23%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	70/260 (27%)
ADGRF5	XP_005248949.1	SEA	170..259	CDD:279699
		IG_like	285..361	CDD:214653
		IGc2	285..351	CDD:197706
		IG_like	517..602	CDD:214653	11/51 (22%)
		GPS	994..1036	CDD:280071	11/60 (18%)
		7tm_4	1051..1302	CDD:304433	70/261 (27%)
		7tm_1	1070..1308	CDD:278431	61/248 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810