DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and ADGRG5

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001291305.1	Gene:	ADGRG5 / 221188	HGNCID:	19010	Length:	528	Species:	Homo sapiens

Alignment Length:	632	Identity:	141/632 - (22%)
Similarity:	235/632 - (37%)	Gaps:	162/632 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSD-EAETATTGV 279
            |..:..|    |.|....|||.....:..|||:.:.   |.:.|.....::.... |.....|..
Human     4 CGALFLC----LCLLTLQNATTETWEELLSYMENMQ---VSRGRSSVFSSRQLHQLEQMLLNTSF 61

  Fly   280 ETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVK 344
            ..||.:      |.|..|........|| .:||::.||. .:|...|.|
Human    62 PGYNLT------LQTPTIQSLAFKLSCD-FSGLSLTSAT-LKRVPQAGG---------------- 102

  Fly   345 EESNLETAAFLPENLWRQV-KSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSN 408
            :.:..:.|...|..|.|.. |:|.....:..:|..:..|.:.      :..|.:::..:.|.:.:
Human   103 QHARGQHAMQFPAELTRDACKTRPRELRLICIYFSNTHFFKD------ENNSSLLNNYVLGAQLS 161

  Fly   409 YLSLPLPFLLRNENLRNPDSKAFSIGSG-------CGYWN-------YETWSTEGVSTE--SSSD 457
            :..:        .|||:|.:.:|.....       |.:|.       :..||.||..||  |.|.
Human   162 HGHV--------NNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQ 218

  Fly   458 LLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEI----LITPINEKVLDIISIVGCSLSLLGILG 518
            :|      |..||||.||.|:       .|...:    |:.|     |..||:||||:|::..|
Human   219 VL------CRCNHLTYFAVLM-------QLSPALVPAELLAP-----LTYISLVGCSISIVASL- 264

  Fly   519 IFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALV---VNGNTVRCVALGAAM 580
              :|..|...:|.|:.:...:|:.|...:.::...||    :|.|..   |.|:.  |.||.||:
Human   265 --ITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFL----LSPAFAMSPVPGSA--CTALAAAL 321

  Fly   581 QYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSY---- 641
            .|::|...:||.|..|..:.....|..| ...||:.|..::.|..|.:..||...:....|
Human   322 HYALLSCLTWMAIEGFNLYLLLGRVYNI-YIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCT 385

  Fly   642 VPSAAQLSTDTG-----ICY----------PSGYGLIFGVVLPVTLITVCNLVIFVYVFYSI--- 688
            :|........||     ||:          ..|||         .|.::.|||:..:..:::
Human   386 IPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYG---------GLTSLFNLVVLAWALWTLRRL 441

  Fly   689 -SHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWI-----FGIFAFMQAGVAFSYLFCITATMQ 747
             ..:.:.|:......:.|      :.|..|||.||.     ||:|...|.     :||.|..::.
Human   442 RERADAPSVRACHDTVTV------LGLTVLLGTTWALAFFSFGVFLLPQL-----FLFTILNSLY 495

  Fly   748 GFVMFIYFVLLDSTNRRLWVGLICPTKMELDVQKRTTELQSMTTSST 794
            ||.:|::|               |..:...:.:.: .::::.::|.|
Human   496 GFFLFLWF---------------CSQRCRSEAEAK-AQIEAFSSSQT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	16/46 (35%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	70/280 (25%)
ADGRG5	NP_001291305.1	GPS	187..232	CDD:307782	18/50 (36%)
		7tmB2_GPR114	245..518	CDD:320559	75/323 (23%)
		TM helix 1	247..272	CDD:320559	12/32 (38%)
		TM helix 2	281..303	CDD:320559	5/25 (20%)
		TM helix 3	315..342	CDD:320559	10/26 (38%)
		TM helix 4	355..375	CDD:320559	5/19 (26%)
		TM helix 5	409..438	CDD:320559	7/37 (19%)
		TM helix 6	451..478	CDD:320559	7/32 (22%)
		TM helix 7	482..507	CDD:320559	9/44 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6566
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910