DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	765	Identity:	177/765 - (23%)
Similarity:	295/765 - (38%)	Gaps:	196/765 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 ATLHDV----CLLRNGMPVTRECRVKDNRANWESTEHWDPV---VCLRRFREHTISGDLNSLHDD 152
            |||..|    |..:.|..:||.|     .:|..|| .|.||   .|.|:         .|.:.::
Mouse   549 ATLPSVYKQPCPNKPGFFMTRAC-----LSNGTST-FWGPVDTSNCSRQ---------SNEVANE 598

  Fly   153 VLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDK--DATVSVDLVSV 215
            :|   .:|.|                  |.||..|:::...:....::.:::  |.|:...|:::
Mouse   599 IL---NQTGD------------------GQNLTSANINSIVEKVKRIVNKEENIDITLGSTLMNI 642

  Fly   216 CKEIM-SCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGV 279
            ...|: |.||.:|..|.:...|          :|.|..::               |...|....:
Mouse   643 FSNILSSSDSDLLESSTEALKT----------IDELAFKI---------------DLNSTPHVNI 682

  Fly   280 ETYNFSDIGVQALITG-----NISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSED 339
            ||.|.: :||.:||.|     |.|:           ||.         ..:.|.|...|.....|
Mouse   683 ETQNLA-LGVSSLIPGTNAPSNFSI-----------GLP---------SNNESYFQMDFGNGQTD 726

  Fly   340 -LAKVKEESNLETAAFLPENLWRQVKSRGATYL---IFKVYAHDALFVETSLQRTRKPRSKVISI 400
             ||.|          .||.||...:....:..:   .|..:....||.:...|| :...|.|::.
Mouse   727 PLASV----------ILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGSQR-KVLVSYVMAC 780

  Fly   401 SIPGLRSNYLSLPLPFLL---RNENLRNPDSKAFSIGSGCGYW------NYETWSTEGVSTESSS 456
            ||..:....|..|:...:   |.:.:.:|.         |.:|      ::..|:|.|....|..
Mouse   781 SIGNITIQNLKDPVQIKIKHTRTQEVHHPI---------CAFWDMNKNKSFGGWNTSGCVAHSDL 836

  Fly   457 DLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFL 521
            |..:..   |..:|.|.|..|:.....|:.:...      |.|||..|:.:||.:|.:......|
Mouse   837 DAGETI---CLCSHFTHFGVLMDLPRSASQIDGR------NTKVLTFITYIGCGISAIFSAATLL 892

  Fly   522 TAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVN-GNTVRCVALGAAMQYSIL 585
            |...|:..|....:|:|::|..|:       :|||...:.:..|.: |....|.|:.|.:.:.:|
Mouse   893 TYVAFEKLRRDYPSKILMNLSSAL-------LFLNLIFLLDGWVTSFGVAGLCTAVAALLHFFLL 950

  Fly   586 VLFSWM------LIIAFLQ-FQRYVTVIGIERPPRYILKAAIVAWLLP--LVPTLLVALIDPDSY 641
            ..|:||      :.||.:: |..|:        .|||||..|:.|.||  :|..:||:....:.|
Mouse   951 ATFTWMGLEAIHMYIALVKVFNTYI--------HRYILKFCIIGWGLPALVVSIILVSRRQNEVY 1007

  Fly   642 VPSAAQLSTDTGICY---P-------SGYGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSI 696
            ...:.....|...|:   |       :||   |||:.      ..|:.:|:.|...|.....:..
Mouse  1008 GKESYGKDQDDEFCWIQDPVVFYVSCAGY---FGVMF------FLNVAMFIVVMVQICGRNGKRS 1063

  Fly   697 HKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDST 761
            ::..::.|::.:|..:.|.||||:||.|..||:....:.|.|||.|..::||..:||:...:...
Mouse  1064 NRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKEN 1128

  Fly   762 NRRLWVGLICPTKMEL----DVQKRTTEL---------QSMTTSSTNYNS 798
            .::.|...:|..:..|    |..|..|.:         :|:::||...||
Mouse  1129 VQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNS 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	10/43 (23%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	74/269 (28%)
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001
		LamG	188..347	CDD:389952
		HRM	543..588	CDD:382965	15/44 (34%)
		GPS	809..854	CDD:366827	12/56 (21%)
		7tm_GPCRs	869..1137	CDD:391938	78/291 (27%)
		TM helix 1	871..896	CDD:341315	8/24 (33%)
		TM helix 2	906..928	CDD:341315	7/28 (25%)
		TM helix 3	939..966	CDD:341315	6/26 (23%)
		TM helix 4	981..997	CDD:341315	6/15 (40%)
		TM helix 5	1026..1049	CDD:341315	7/31 (23%)
		TM helix 6	1072..1097	CDD:341315	11/24 (46%)
		TM helix 7	1101..1126	CDD:341315	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6570
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910