DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11318 and CELSR2

DIOPT Version :9

Sequence 1:NP_651842.3 Gene:CG11318 / 43678 FlyBaseID:FBgn0039818 Length:802 Species:Drosophila melanogaster
Sequence 2:NP_001399.1 Gene:CELSR2 / 1952 HGNCID:3231 Length:2923 Species:Homo sapiens


Alignment Length:863 Identity:185/863 - (21%)
Similarity:298/863 - (34%) Gaps:288/863 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PIYSACPKENQMCLRNGTF----QYCDGEERNSSDELMQTHLVYCTSM-FCEPEEFQHDYITRNH 77
            |..:.|||        |:|    ::|| |.|.    .:..:|..|||: |.|.:.|..       
Human  1994 PAAAPCPK--------GSFGTAVRHCD-EHRG----WLPPNLFNCTSITFSELKGFAE------- 2038

  Fly    78 DQTPHQNKWKRARIGERATLHDVCLLRNGMPVTRECRVKDNRANWESTEHWDPVVCLRRFREHTI 142
                                                |::.|.:..:|.......:.||...:|| 
Human  2039 ------------------------------------RLQRNESGLDSGRSQQLALLLRNATQHT- 2066

  Fly   143 SGDLNSLHDDVLEGRRRTNDTQGRREM-TGIMRNMFRQRG-GNLLPADVHMTGQMFGALMQQDKD 205
            :|...|             |.:...:: |.::.:...||| |.....|||.|             
Human  2067 AGYFGS-------------DVKVAYQLATRLLAHESTQRGFGLSATQDVHFT------------- 2105

  Fly   206 ATVSVDLVSVCKEIMSCDSKVLRL-SAQLNATNS---------------LLSQFESYMDALPEQL 254
                              ..:||: ||.|:..|.               ||..:|:|..||.:.:
Human  2106 ------------------ENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNM 2152

  Fly   255 VPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLAIFSAPG 319
                  ......|.:         :.|.|.. |.|..|..||    ||..:..|...|.     |
Human  2153 ------RHTYLSPFT---------IVTPNIV-ISVVRLDKGN----FAGAKLPRYEALR-----G 2192

  Fly   320 DQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVK-------------------- 364
            :|                        ..:|||...|||:::|:..                    
Human  2193 EQ------------------------PPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARR 2233

  Fly   365 -------SRG---ATYLIFKVYA----HDALFVETSLQRTRKP--RSKVISISI---PGLRSNYL 410
                   |:|   |:.:|::..|    |:....:.||:..::|  .:.|:|||:   ..|....|
Human  2234 QRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRAL 2298

  Fly   411 SLPLPF---LLRNENLRNPDSKAFSIGSGCGYWNYET-------WSTEGVSTESSSDLLKDAIIE 465
            ..|:..   ||..|....|.         |.:||:..       ||..|....    ...::.:.
Human  2299 DKPVTVQFRLLETEERTKPI---------CVFWNHSILVSGTGGWSARGCEVV----FRNESHVS 2350

  Fly   466 CHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWR 530
            |..||:|.||.|:..|.|.|  ||   |.|:  |.|..::: |.:|:.|.:...|||  |.:..|
Human  2351 CQCNHMTSFAVLMDVSRREN--GE---ILPL--KTLTYVAL-GVTLAALLLTFFFLT--LLRILR 2405

  Fly   531 SQASTKVLLHLCLAMCLQMMLFVF-LNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLII 594
            |. ...:..:|..|:.|..::|:. :|..|:..|         |..:...:.:..|..|||.|:.
Human  2406 SN-QHGIRRNLTAALGLAQLVFLLGINQADLPFA---------CTVIAILLHFLYLCTFSWALLE 2460

  Fly   595 AFLQFQRYVTVIGIERPPR---YILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICY 656
            |...::....|..:...|.   |:|     .|.:|...|.|...:||:.|        .:...|:
Human  2461 ALHLYRALTEVRDVNTGPMRFYYML-----GWGVPAFITGLAVGLDPEGY--------GNPDFCW 2512

  Fly   657 PSGYG-LIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGL 720
            .|.|. ||:....||..  ..::.:|:|:..:.:...:|. ...|||..|..::.|..:..||..
Human  2513 LSIYDTLIWSFAGPVAF--AVSMSVFLYILAARASCAAQR-QGFEKKGPVSGLQPSFAVLLLLSA 2574

  Fly   721 TWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMELDVQKRTTE 785
            ||:..:.:.....:.|.|||.....:||..:|:.:|:|....|:. :.|.|..|...|       
Human  2575 TWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKA-LKLACSRKPSPD------- 2631

  Fly   786 LQSMTTSST---NYNSRS 800
             .::||.||   :||..|
Human  2632 -PALTTKSTLTSSYNCPS 2648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11318NP_651842.3 GPS 437..475 CDD:280071 10/44 (23%)
7tm_4 500..750 CDD:304433 60/254 (24%)
CELSR2NP_001399.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..198
Cadherin_repeat 185..285 CDD:206637
Cadherin_repeat 293..395 CDD:206637
Cadherin_repeat 404..501 CDD:206637
Cadherin_repeat 509..606 CDD:206637
Cadherin_repeat 614..708 CDD:206637
Cadherin_repeat 716..811 CDD:206637
Cadherin_repeat 819..917 CDD:206637
Cadherin_repeat 925..1019 CDD:206637
Cadherin_repeat 1042..1120 CDD:206637
EGF_CA 1289..1324 CDD:238011
EGF_CA 1333..1366 CDD:238011
LamG 1369..1552 CDD:238058
EGF_CA 1578..1609 CDD:238011
LamG 1618..1767 CDD:238058
EGF_CA 1795..1829 CDD:238011
EGF 1832..1865 CDD:278437
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468 16/52 (31%)
GAIN 2052..2287 CDD:293098 61/328 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2238 0/24 (0%)
GPS 2315..2368 CDD:197639 15/65 (23%)
7tm_4 2402..2605 CDD:304433 52/228 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2688..2838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2854..2888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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