DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and lat-1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	682	Identity:	151/682 - (22%)
Similarity:	271/682 - (39%)	Gaps:	154/682 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 ANWESTEHWDPVVCLRRFREHTISGDLNSLHDDV--LEGRRRTNDTQGRREMTGIMRNMFRQRGG 182
            :||.|:            |...:||.::|  :||  |....|...::.||.|.          ||
Worm   237 SNWISS------------RNSVLSGVISS--EDVSGLPEFLRNLGSETRRPMV----------GG 277

  Fly   183 NLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESY- 246
            : ||..:|:.            :.||:|    :.:|..:.....|.....:...|.:|...|.:
Worm   278 D-LPKVLHLL------------EKTVNV----IAEESWAYQHLPLSNKGAVEVMNYMLRNQEIWG 325

  Fly   247 -MDALPEQLVPKDRCGKVVAKPTSDEAETATT-GVETYNFSDIGVQALITGNISVFFANPECDRI 309
             .|....    |:...:.:.  .:::|..|:. |:.|...|::.||..||..||
Worm   326 SWDVTKR----KEFASRFIL--AAEKAMVASAKGMMTSAESNVIVQPAITVEIS----------- 373

  Fly   310 TGLAIFSAPGDQRKTSASGFW----YRFIRFSED-LAKV-KEESNLETAAFLPENLWRQVKSRGA 368
            ..:.:.|.|.|.....::..|    ...:....| :.|: |:|:.:..::|  :||..|:.....
Worm   374 HKIKMSSQPTDYILFPSAALWNGQNVDNVNIPRDAILKINKDETQVFFSSF--DNLGAQMTPSDV 436

  Fly   369 TYLIFKVYAHDALFVETSLQRTRKPR--SKVISISI----PGLRSNYLSLP--LPFLLRNENLR- 424
            |..|          ..|.....||.|  |:::..|:    ...|...|:.|  :.|..:..::|
Worm   437 TVAI----------AGTDQTEVRKRRVVSRIVGASLIENGKERRVENLTQPVRITFYHKESSVRH 491

  Fly   425 --NPDSKAFSIGSGCGYWNYE--TWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRAN 485
              ||.         |.:||:.  .|...|......:    ..:..|...|||.||.|:  ..|.:
Worm   492 LSNPT---------CVWWNHHELKWKPSGCKLSYHN----KTMTSCDCTHLTHFAVLM--DVRGH 541

  Fly   486 DLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLH--LCLAMCLQ 548
            ||.|      |::.:|.:::.|||.:|::.:|..|....:|.   .....:|.:|  |||::.:.
Worm   542 DLNE------IDQTLLTLLTYVGCIISIICLLLTFFAYLIFS---RNGGDRVFIHENLCLSLAIA 597

  Fly   549 MMLFV--FLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERP 611
            .:.|:  ...|:|          :::|..:..|:.|..|...:|||:..: ...|.:|.:....|
Worm   598 EITFLAGITRTED----------SLQCGIIAVALMYMFLSALTWMLLEGY-HIHRMLTEVFPSDP 651

  Fly   612 PRYILKAAIVAWLLPLVPTLLVALIDPDSY-VPSAAQLSTDTGICY----PSGYGLIF---GVVL 668
            .|:..  .:|.::.|.:.||:..|.:.|.: .|....|||.....:    |:.:  ||   .:||
Worm   652 RRFTY--LLVGYIPPAIITLVAYLYNSDGFGTPDHCWLSTQNNFIWFFAGPACF--IFCANSLVL 712

  Fly   669 PVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQA- 732
            ..||.||.......|:  ...|.:...      :.:...::.|:.|..|||:|||||:|....:
Worm   713 VKTLCTVYQHTSGGYL--PCRHDVDSG------RSIRNWVKGSLALASLLGVTWIFGLFWVEDSR 769

  Fly   733 GVAFSYLFCITATMQGFVMFIYFVLLDSTNRR 764
            .:..:|:|.|:.::||..:|::.|:.....|:
Worm   770 SIVMAYVFTISNSLQGLFIFLFHVVFAEKMRK 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	9/39 (23%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	64/262 (24%)
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468	3/18 (17%)
		GAIN	258..462	CDD:406802	50/259 (19%)
		GPS	493..541	CDD:197639	15/62 (24%)
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	67/280 (24%)
		TM helix 1	551..575	CDD:320556	7/23 (30%)
		TM helix 2	584..605	CDD:320556	6/20 (30%)
		TM helix 3	615..637	CDD:320556	6/21 (29%)
		TM helix 4	655..671	CDD:320556	4/17 (24%)
		TM helix 5	690..713	CDD:320556	4/24 (17%)
		TM helix 6	744..766	CDD:320556	11/21 (52%)
		TM helix 7	771..796	CDD:320556	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910