DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and Adgrl4

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_573485.2	Gene:	Adgrl4 / 170757	MGIID:	2655562	Length:	739	Species:	Mus musculus

Alignment Length:	687	Identity:	153/687 - (22%)
Similarity:	233/687 - (33%)	Gaps:	216/687 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 SVCKEIMSC-DSKVLRLSAQLNATNSLLSQF--ESYMDAL-PEQLVPKD---------------- 258
            |.|::|..| :|.|....|.....|...|.|  |.|..|. ..|..|.|
Mouse   104 SYCQDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQESMNSNCHLEH 168

  Fly   259 ------------RCGKVVAKPT-------SDEAETATTGVETYNFSDIGVQALITGNISVFFANP 304
                        |.|.:..:.|       :.|||.:...:.||      ::.|...:
Mouse   169 ACIAANINKTLKRIGPITEQTTLLQEIYRNSEAELSLMDIVTY------IEILTESS-------- 219

  Fly   305 ECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWR-------- 361
                    ::...|........:.|......|.|.:....|.|..:....||.|..|
Mouse   220 --------SLLGHPNSTTSYKDAHFNSTLTEFGETINNFVERSTHKMWDQLPTNHRRLHLTKLMH 276

  Fly   362 -------------QVKSR---GATYLIFKVYAHDAL--------------FVETSLQRTRKPRSK 396
                         |..|:   .:|.|..||:|.|:.              :|:.|      ||.|
Mouse   277 TAELVTLQIAQNTQKNSQFDMNSTDLALKVFAFDSTHMKHAHPHMNVDGGYVKIS------PRRK 335

  Fly   397 VISISIPGLRSN-------YLSL-PL-----PFLLRNENLRNPDSK--------AFSIGSG---- 436
                :..|...|       |.|: ||     .|||..:| .|.:.|        :.||.|.
Mouse   336 ----AAHGTTGNVVVAFLCYKSIGPLLSSSDNFLLDTQN-DNSEGKEKVISSVISASISSNPPTL 395

  Fly   437 ----------------------CGYWNYE-------TWSTEGVSTESSSDLLKDAIIECHTNHLT 472
                                  |.:|||.       :|||||.....|:    |....|..:|||
Mouse   396 YELEKITFTLSHVKLSDKHRTQCAFWNYSVDAMNNGSWSTEGCELTHSN----DTHTSCRCSHLT 456

  Fly   473 QFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSW--RSQAST 535
            .||.|:..:       ..|.|...|  :|..|:.:|..:||     |.|...:|..|  ....||
Mouse   457 HFAILMSST-------SSIGIKDYN--ILTRITQLGIIISL-----ICLAICIFTFWFFSEIQST 507

  Fly   536 KVLLH--LCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQ 598
            :..:|  ||.::.|..::|:.        .:.:|.|.:.|..:...:.|..|..|:||.|..
Mouse   508 RTTIHKNLCCSLFLAELVFLI--------GININTNKLVCSIIAGLLHYFFLAAFAWMCIEG--- 561

  Fly   599 FQRYVTVIGIERPPRYILK-AAIVAWLLPLVPTLLVALIDPDSY-VPSAAQLSTDTGICYPSGYG 661
            ...|:.|:|:.....::.| ..|..:|.|.|.....|.:....| ......|||:.        .
Mouse   562 IHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTEN--------N 618

  Fly   662 LIFGVVLPVTLITVCNLVIFVYVFYSI-SHSL----SQSIHKNEKKMVVKQIRLSIMLFFLLGLT 721
            .|:..:.|..||.:.||:.|..:.|.: .|:.    ..|.::|.:...    |.::.|.||||.|
Mouse   619 FIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCA----RGALALLFLLGTT 679

  Fly   722 WIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLL 758
            ||||:...:.|.|..:|||.::...||..:|::..:|
Mouse   680 WIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	15/44 (34%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	67/260 (26%)
Adgrl4	NP_573485.2	EGF_CA	58..91	CDD:214542
		EGF_CA	108..141	CDD:214542	10/32 (31%)
		GAIN	190..370	CDD:293098	39/211 (18%)
		GPS	417..461	CDD:280071	17/47 (36%)
		7tm_4	473..709	CDD:304433	68/265 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810