DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	886	Identity:	199/886 - (22%)
Similarity:	331/886 - (37%)	Gaps:	220/886 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FVVLALVSPIYSACPKENQMCLRNGTFQYCDGEERN---------------------SSDELMQ- 52
            |.:..|.:.|.|....|.:|.:.....:..:|:|..                     :|.|||:
Human  2284 FSLATLETQIKSRDISEEEMVMDRAILEQREGQEMATISYVPYSCVCQVIIKASSSLASSELMRK 2348

  Fly    53 ---------TH----------LVYCTSMF---CEPEEFQHDYITRNHDQTPHQNKWKRARIGERA 95
                     ||          ||.|..:.   .||...:.|.....:..|   .||......|.|
Human  2349 IKSKIHGNFTHGNFTQDQLTLLVNCEHVAVKKLEPGNCKADETASKYKGT---YKWLLTNPTETA 2410

  Fly    96 TLHDVCLLRNGMPVTRECRVKDN--RANWESTEHWDPVVCLRRFREHTISGDLNSLHDDVLEGRR 158
            ...  |:.......||.|.:..|  ::.||..          :|::..:   |..|.|.:::...
Human  2411 QTR--CIKNEDGNATRFCSISINTGKSQWEKP----------KFKQCKL---LQELPDKIVDLAN 2460

  Fly   159 RTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSCD 223
            .|...:...::...:.|:.     |..||              ..|:.|..:  ||...:|..||
Human  2461 ITISDENAEDVAEHILNLI-----NESPA--------------LGKEETKII--VSKISDISQCD 2504

  Fly   224 SKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIG 288
                  ...:|.|:.:|            |::      .||.:..::.|.         :..:|.
Human  2505 ------EISMNLTHVML------------QII------NVVLEKQNNSAS---------DLHEIS 2536

  Fly   289 VQAL----ITGNISVFFANPECDRITGLAIFSAPGDQRKTSASGFWYRFIRFSED------LAKV 343
            .:.|    .||:...|........:.|||:....||.   :..|..:....:.|.      |..|
Human  2537 NEILRIIERTGHKMEFSGQIANLTVAGLALAVLRGDH---TFDGMAFSIHSYEEGTDPEIFLGNV 2598

  Fly   344 KEESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSN 408
             ....:..:.:||::|..::.......::|..:...:||...::  |:...:.|:|.||    |:
Human  2599 -PVGGILASIYLPKSLTERIPLSNLQTILFNFFGQTSLFKTKNV--TKALTTYVVSASI----SD 2656

  Fly   409 YLSLPLPFLLRNENLRNPDSKAFS-IGSG-------CGYWNYET------WSTEGVSTESSSDLL 459
            .:.:        :||.:|...... ||..       |.:|::|.      |::.|...:.::  :
Human  2657 DMFI--------QNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETN--V 2711

  Fly   460 KDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAA 524
            ...|.:|  :|||.|..|:       ||... .:..:||::|.:|:..||     ||..|||..|
Human  2712 NYTICQC--DHLTHFGVLM-------DLSRS-TVDSVNEQILALITYTGC-----GISSIFLGVA 2761

  Fly   525 L-----FKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSI 584
            :     |...|.....|:|::||.|  |.|:..|||....:|....|.    .|:....|:.|.:
Human  2762 VVTYIAFHKLRKDYPAKILINLCTA--LLMLNLVFLINSWLSSFQKVG----VCITAAVALHYFL 2820

  Fly   585 LVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLS 649
            ||.|:||.:.|...:...|.|..| ..|.||||..:|.|.:|.:...:...:..|.|    ..||
Human  2821 LVSFTWMGLEAVHMYLALVKVFNI-YIPNYILKFCLVGWGIPAIMVAITVSVKKDLY----GTLS 2880

  Fly   650 TDTGICYPSGYGLIF-GVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIM 713
            ..|..|:.....:.: .||....||.:.||.:|..|...: :|:...|.|..:||::..::.::.
Human  2881 PTTPFCWIKDDSIFYISVVAYFCLIFLMNLSMFCTVLVQL-NSVKSQIQKTRRKMILHDLKGTMS 2944

  Fly   714 LFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMELD 778
            |.|||||||.|..||:......|.|||.|..|:|||.:|::..::..:.|..|...:|...:.||
Human  2945 LTFLLGLTWGFAFFAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLCCGWLRLD 3009

  Fly   779 -------------------VQK------RTTELQSMTTSST 794
                               ::|      .|..|:|..||||
Human  3010 NSSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSLKSTATSST 3050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	10/43 (23%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	82/255 (32%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071	11/46 (24%)
		7tm_2	2743..2982	CDD:278432	83/255 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080		199/886 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6566
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5250
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940