DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgre14

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_021330419.1	Gene:	adgre14 / 108182849	ZFINID:	ZDB-GENE-131120-49	Length:	505	Species:	Danio rerio

Alignment Length:	398	Identity:	99/398 - (24%)
Similarity:	178/398 - (44%)	Gaps:	72/398 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 SKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNYETWSTEGVSTESSSDLL 459
            |.|||:::|...:..||.|:.|..|:....:| |.:||    |.|||...|..:|.|..:::
Zfish   130 SSVISVTLPKTTNTALSKPVNFTFRHIREFDP-SGSFS----CVYWNISKWIVDGCSVLNTN--- 186

  Fly   460 KDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAA 524
             .:...|...||:.||.::  ..|::        .|.::.:|:::::| |  .::|:|  |.:.|
Zfish   187 -RSFTVCSCVHLSTFALIM--QTRSH--------PPESDSLLNVLNVV-C--VIVGLL--FFSLA 235

  Fly   525 LFKSWRSQASTKV----LLHLCLAMCLQMMLFV----FLNTDDVSEALVVNGNTVRCVALGAAMQ 581
            |....|.|.|..|    .:::|:::.|..:||:    ||:        ::....|.|:.:...:.
Zfish   236 LLTFTRCQWSPGVNNVARINICISLLLAHLLFLLTQQFLS--------LIRRQKVLCMLISGLLH 292

  Fly   582 YSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILK---AAIVAWLLPLVPTLLVALIDPDSYVP 643
            :..|..|.||.|.|.|.|.....:..|....:.:|:   ..::.:.:.||...:.|.:.|:.|..
Zfish   293 FLFLSGFVWMFIEAVLLFICVKNLSQISSQMKNVLRNKLLCVIGYAVALVVVSISAAVVPNGYGS 357

  Fly   644 SAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHK--------NE 700
            ....:....        |.|:..:.|||:|...|:::|:    ||..||..:..|        |:
Zfish   358 EKCWIQMHK--------GFIWSFLGPVTIIIALNVILFI----SIGFSLKSAFKKLNADVSQLNQ 410

  Fly   701 KKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGVAFSYLFCITATMQG-FVMFIYFVL---LDST 761
            .|:|:.:   ::..|.:||.:||.|.|.  .:......||.|..:.|| |:..||.||   :...
Zfish   411 TKIVMFK---TLAQFVVLGCSWILGFFT--NSSKVLEILFLILNSQQGTFIFLIYCVLNKGIRQE 470

  Fly   762 NRRLWVGL 769
            .|:|:..|
Zfish   471 YRKLFTSL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	10/37 (27%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	63/269 (23%)
adgre14	XP_021330419.1	GPS	167..205	CDD:197639	12/43 (28%)
		7tm_GPCRs	214..476	CDD:333717	70/291 (24%)
		TM helix 1	217..241	CDD:320095	8/28 (29%)
		TM helix 2	250..271	CDD:320095	4/20 (20%)
		TM helix 3	285..307	CDD:320095	5/21 (24%)
		TM helix 4	331..347	CDD:320095	2/15 (13%)
		TM helix 5	365..388	CDD:320095	7/30 (23%)
		TM helix 6	412..435	CDD:320095	8/25 (32%)
		TM helix 7	439..464	CDD:320095	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4884
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.860