DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgre5b.2

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_005160278.1	Gene:	adgre5b.2 / 101882660	ZFINID:	ZDB-GENE-121214-277	Length:	693	Species:	Danio rerio

Alignment Length:	764	Identity:	173/764 - (22%)
Similarity:	278/764 - (36%)	Gaps:	218/764 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NWESTEHWDPVVCLRRFREHTISGDLN---------------SL----------HDDVLEGRRRT 160
            |..:|...||.:.:....:..||||.:               ||          ..||:...:.:
Zfish    46 NGPTTASADPDLEISGDTDSEISGDSDLEISSQPYLTMSTQASLDITASSFPAHRQDVIRATQTS 110

  Fly   161 NDT--------QGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCK 217
            ..|        :|..|.|.|..:.|:.:     |.:.| |.:....:|...||
Zfish   111 ETTSQNAFVSPKGAAEQTEIECDQFKSK-----PDEDH-TPEKLNQMMSLLKD------------ 157

  Fly   218 EIMSCDSKVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVV---------------AKP 267
               ||:|....:....||...|.:...|..|.|.|        |||.               .:.
Zfish   158 ---SCESLNDPVEKHFNAEELLENLCNSTDDLLLE--------GKVADGENLSVFLDMVENSMRL 211

  Fly   268 TSDEAETATTGVETYN-FSDIGV---QALITGNISVFFANPECDRITGLAIFSAPGDQRKTSA-S 327
            ...:.:...|.:||.| ::::.:   |...:|::::         .|..|:||...:.....| |
Zfish   212 IGPQLKDPVTKMETQNTYAEVALTRNQTPPSGSVTL---------STDSALFSTSWETVVGKAYS 267

  Fly   328 G------FWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQ--VKSRGATYLIFKVYAHDALFVE 384
            |      |.|:.:..|.||:.       :|:..|.|:..::  |..:..||.:
Zfish   268 GFAFVALFSYKDMNSSSDLSH-------KTSRTLQEDSRKRLHVDEKKITYQL------------ 313

  Fly   385 TSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWN--YETWST 447
                     .|||::..:....:..||..:.....:|..|   :::..:...|.|||  .:.||.
Zfish   314 ---------NSKVVTAVVSNPDTKKLSDLMMLTFTHEEER---AESGGVAYTCVYWNESEKVWSG 366

  Fly   448 EGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRANDLGEEILITPINEKVLDIISIVGCSLS 512
            .|...|.|:    .....||.:||:.||.|: ..|...|....:|||.           ||..||
Zfish   367 RGCVKEWSN----STHTVCHWSHLSSFAVLM-ALYPVQDTFASVLITR-----------VGLVLS 415

  Fly   513 LLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALG 577
            |   |.:||....|:..||...|:..:||.|::||.:...|||.      .:....|.|.|..:.
Zfish   416 L---LCLFLCILTFRFCRSIQGTRNSIHLHLSVCLFIADLVFLC------GISSTHNQVACAIVA 471

  Fly   578 AAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYILKAAIVAWLLPLVPTLLVALIDPDSYV 642
            ..:.:..|..|.|||:.....::..|.|........|:.   .|.:.:|||   :|::
Zfish   472 GLLHFFFLSAFCWMLLEGVQLYRMVVLVFHTTLKHLYLY---AVGYGVPLV---IVSI------- 523

  Fly   643 PSAAQLSTDTGICYPSGYG------------LIFGVVLPVTLITVCNLVIFVYV-------FYSI 688
                     :.|.:|.|||            ||.....||.:|.:.|:::|:..       |.|:
Zfish   524 ---------SAITFPKGYGTNKHCWLSLEGYLILSFFAPVCIIVILNIIVFIITVWKLALKFSSL 579

  Fly   689 SHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGV-AFSYLFCITATMQGFVMF 752
            :..||: :||....:.....:|.:     ||.:|:||.|.|.:.|. ...|||.|..::||.::|
Zfish   580 NPDLSK-LHKIRSFLATAVAQLCV-----LGGSWVFGFFLFQKNGTEVMLYLFIILNSLQGALIF 638

  Fly   753 IYFVLLDSTNRRLWVGL---ICPTKMELDV----------QKRTTELQS 788
            |...||....|..:..|   :||.|.:.|.          |||....||
Zfish   639 IMHCLLSKQVRVEYHSLFVRMCPYKKKGDYSVSTEPSHSSQKRLQSDQS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	13/39 (33%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	69/269 (26%)
adgre5b.2	XP_005160278.1	GPS	353..398	CDD:197639	17/49 (35%)
adgre5b.2	XP_005160278.1	7tm_4	406..637	CDD:304433	72/278 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4884
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960