DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgrg7.1

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_021325139.1	Gene:	adgrg7.1 / 101882620	ZFINID:	ZDB-GENE-060503-894	Length:	1200	Species:	Danio rerio

Alignment Length:	817	Identity:	171/817 - (20%)
Similarity:	300/817 - (36%)	Gaps:	230/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALVSPIYS--ACPKENQMCLRNGTFQ----YC-DGEERNSSDELMQTHLVYCTSMFCEPEEFQHD 71
            |:.|..:|  |....|.:|..:||||    .| ||          .|........||..:.|
Zfish   493 AVTSTTFSAAAATSPNLVCENSGTFQKGICLCPDG----------WTGTTCNIPNFCPGQTF--- 544

  Fly    72 YITRNHDQTPHQNKWKRARIGERATLHDVCLLRN---GMP-VTRECRVKDNRANWESTEHWDP-- 130
                   .||:...:.:..:|:.|:..:.|....   |:| .:..|.:        .|..::|
Zfish   545 -------PTPNAFTFPKTVLGQFASSVEQCPSNTPNAGIPQASALCNI--------ITRTFEPPN 594

  Fly   131 -VVCLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQ 194
             |.|         :..|:|::.||  .....||.:.....|.|:.::..:.....:...|.:|..
Zfish   595 QVKC---------NLTLDSINADV--PGANLNDKKVLASSTQILTSIPERLTSQNITNAVKITHF 648

  Fly   195 MFGALMQQDKD-------ATVSVDLVSVCKEIMSCDSKVLRLSAQLNATNSLLSQFESYMDALPE 252
            :.......|::       |||| .|:|..:||.|..|:         :..|||:|....: :|.|
Zfish   649 LLSNQQTTDQNDIVVSAVATVS-QLLSTREEIFSSVSR---------SAVSLLTQTLQKI-SLSE 702

  Fly   253 QLVPKDRCGKVVAKPT----SDEAETATTGVETYNFSDIGVQALITGNISVFFANPECDRITGLA 313
            ...|      ::.:|.    |.:.:||...|:...|.  |:..|             .|.:.|::
Zfish   703 NSSP------LLVQPNIAMQSLKGQTAIRHVQLTYFK--GISTL-------------KDLLRGMS 746

  Fly   314 IFSAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAFLPENLWRQVKSRGATYLIFKVYAH 378
            :.:             :..|:.|::|:.                               |.:|.:
Zfish   747 VIT-------------FCSFVDFNKDIG-------------------------------FVLYDN 767

  Fly   379 DALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRNPDSKAFSIGSGCGYWNY- 442
            |..|...|.|.|...:.:|||.|:|.: :....:...|      ..:.||........|.:|:|
Zfish   768 DRFFQSNSFQPTLDTKRRVISASLPEI-TELDQIKFTF------TESADSTMSLNDFACVFWSYS 825

  Fly   443 -ETWSTEGV--STESSSDLLKDAIIECH-------TNHLTQFAFLVGGSYRANDLGEEILITPIN 497
             ..||.:|.  :|..|..      .||.       ||.....:|.:...|
Zfish   826 KNDWSPDGCFKTTGPSGQ------AECRCLPKTVKTNFAILMSFNINYQY--------------- 869

  Fly   498 EKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSE 562
            .:.|..|||:||:||::|:....:...:.:..|....|.:::::|::|.:..:||:|...:.|..
Zfish   870 SEALSWISIIGCALSVVGLSVTSVYQIITRKSRGTNPTLLVVNVCISMMVFYLLFIFGINNPVKH 934

  Fly   563 ALVVNG--NTV------------RCVALGAAMQYSILVLFSWMLII---AFLQFQRYVTVIGIER 610
            ..|...  |.|            .|....|.:|:.:|..|:|..:.   .||.|:..|:     .
Zfish   935 LTVAKSTQNIVPASDYHTYPDQGPCTVFTALLQFFLLATFTWNTLYGFNVFLLFKNQVS-----G 994

  Fly   611 PPRYILKAAI-VAWLLPLVPTLLVALIDPDSYVPSAAQ------------LSTDTGICYPSGYGL 662
            .|.:..|.|: |.|.||.|   :|.:....:|  |..:            .:.|..:.:..|..:
Zfish   995 TPTWFPKVALPVGWGLPAV---IVGISLGSTY--SVKEPLGYRQEEFCWLAALDHNLNFSMGKPM 1054

  Fly   663 IFGVVLPVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIF 727
            .:|:|||:.|:.:.|..|.::..::|..: :.::.::.|..:..:|..|..|..:|||:|..|..
Zfish  1055 FWGLVLPLLLMLISNAAILLHFSHNICKT-NPNLGRSRKTPLKNKILSSFSLAVMLGLSWSIGYI 1118

  Fly   728 AFMQAGVAFSYL-------FCITATMQGFVMFIYFVL 757
            ..:   |..|||       ||:..|.||..:.|.|.|
Zfish  1119 LLI---VRDSYLQFLLTVVFCVLNTTQGVQILILFTL 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/48 (25%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	69/286 (24%)
adgrg7.1	XP_021325139.1	EGF_2	506..533	CDD:285248	10/36 (28%)
		GPS	819..861	CDD:321989	12/47 (26%)
		7tm_GPCRs	872..1153	CDD:333717	72/295 (24%)
		TM helix 1	873..897	CDD:320095	9/23 (39%)
		TM helix 2	907..928	CDD:320095	6/20 (30%)
		TM helix 3	960..982	CDD:320095	5/21 (24%)
		TM helix 4	1002..1018	CDD:320095	7/18 (39%)
		TM helix 5	1051..1074	CDD:320095	8/22 (36%)
		TM helix 6	1096..1121	CDD:320095	8/24 (33%)
		TM helix 7	1129..1153	CDD:320095	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910