DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and ADGRG2

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001073327.1	Gene:	ADGRG2 / 10149	HGNCID:	4516	Length:	1017	Species:	Homo sapiens

Alignment Length:	663	Identity:	165/663 - (24%)
Similarity:	278/663 - (41%)	Gaps:	126/663 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 PADVHMTGQMFGALMQQDKDATVSVDLVSVCKEIMSCDSKVLRL-------SAQLNATNSLLSQF 243
            ||:|:.|..           ..|..|:|:. ..|...:::||::       |.:.|....:::|.
Human   353 PANVNTTSA-----------PPVQTDIVNT-SSISDLENQVLQMEKALSLGSLEPNLAGEMINQV 405

  Fly   244 ESYMDALPEQLVP-KDRCGKVVAKPTSDEAETATTGVETYNFSDIGVQALITGNISVFFANPECD 307
            ...:.:.|:.|.| ..|..|||                    .|||:| |...|.::...:|.
Human   406 SRLLHSPPDMLAPLAQRLLKVV--------------------DDIGLQ-LNFSNTTISLTSPS-- 447

  Fly   308 RITGLAIFSAPGDQRKTSASGF-WYRFIRFSEDLAKVKEESNLETAA--------FLPENLWRQV 363
              ..||:.       :.:||.| ...|:  ::|.|.:  :.:|||.|        .||.:|...:
Human   448 --LALAVI-------RVNASSFNTTTFV--AQDPANL--QVSLETQAPENSIGTITLPSSLMNNL 499

  Fly   364 KSRG---ATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLRNENLRN 425
            .:..   |:.:.|..:...|||.:.||:.. ...|.|||.|:..|....|:..:...|::   .|
Human   500 PAHDMELASRVQFNFFETPALFQDPSLENL-SLISYVISSSVANLTVRNLTRNVTVTLKH---IN 560

  Fly   426 PDSKAFSIGSGCGYWNYET------WSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRA 484
            |.....::  .|.:|:...      ||..|.|.:...  |.:.|..|  :|||.|..|:
Human   561 PSQDELTV--RCVFWDLGRNGGRGGWSDNGCSVKDRR--LNETICTC--SHLTSFGVLL------ 613

  Fly   485 NDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQM 549
             ||....:: |.....|..|:.:||.||.:.:....:|...|:..|....:|:|:.||.|:.|..
Human   614 -DLSRTSVL-PAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLN 676

  Fly   550 MLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIG--IERPP 612
            ::|:.   |.......:.|   .|:::...:.|.:||.|:||.:.||..:...|.|..  |.
Human   677 LVFLL---DSWIALYKMQG---LCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIR--- 732

  Fly   613 RYILKAAIVAWLLPLVPTLLVALIDPDSY-------VPSAAQLSTDTGICYPSGYGLIF-GVVLP 669
            :||||..||.|.:|.|...::..|.||:|       .|:.   |.| ..|:.:...:.: .||..
Human   733 KYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNG---SPD-DFCWINNNAVFYITVVGY 793

  Fly   670 VTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRLSIMLFFLLGLTWIFGIFAFMQAGV 734
            ..:|.:.|:.:|:.|...:.....:.....::|..::.:|....|.||||:||.|..||:....|
Human   794 FCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNV 858

  Fly   735 AFSYLFCITATMQGFVMFIYFVLLDSTNRRLWVGLICPTKMEL-----------DVQKRTTELQS 788
            .|.|||.|..|:|||.:||::.:.....|:.|...:|..|:.|           :..|:.|..|.
Human   859 TFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQG 923

  Fly   789 MTTSSTNYNSRSH 801
            :::||.:..|.|:
Human   924 VSSSSNSLQSSSN 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/43 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	74/259 (29%)
ADGRG2	NP_001073327.1	GPS	569..612	CDD:280071	13/46 (28%)
ADGRG2	NP_001073327.1	7tm_4	625..875	CDD:304433	75/262 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6566
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7779
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860