DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and LOC100536657

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_005171094.1	Gene:	LOC100536657 / 100536657	-ID:	-	Length:	761	Species:	Danio rerio

Alignment Length:	658	Identity:	160/658 - (24%)
Similarity:	254/658 - (38%)	Gaps:	174/658 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 SVCKEIMSCDSKVLRLSAQLN--ATNSLLSQFESYMDAL---------PEQLVPKDRCGKVVAKP 267
            |.|.| |:||:......|:..  ....||||..|..:||         .|||:..      :...
Zfish   202 SKCIE-MNCDNFKTETEAEEMPIKLKELLSQLRSSCEALVTPDGERKTGEQLMEN------LFTS 259

  Fly   268 TSDEAETATTG-----------------------------VETYN-FSDIGV---QALITGNISV 299
            |.|.....:.|                             :||:| ::::.|   |...:|::.:
Zfish   260 TDDLLSAGSVGDGETLSVLLDTVENSMRLICPQLKEPVMRMETHNTYAEVAVTRNQTPPSGSVIL 324

  Fly   300 FFANPECDRITGLAIF----------SAPGDQRKTSASGFWYRFIRFSEDLAKVKEESNLETAAF 354
                     .||.|:|          |.||           :.|:    .|...|:.::
Zfish   325 ---------STGSALFNTSWETVVGKSYPG-----------FAFV----SLVSYKDMNS------ 359

  Fly   355 LPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRKPRSKVISISIPGLRSNYLSLPLPFLLR 419
             ..||:|.|..:.:.             :|.::  |.|..|||:::.:....:.:||.|:..:..
Zfish   360 -SSNLFRNVSRKKSD-------------MEENV--THKLNSKVVTVVVSNPDTKHLSEPVSLIFT 408

  Fly   420 NENLRNPDSKAFSIGSGCGYW--NYETWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSY 482
            :...| .:|||  :...|.||  :...||.:|.....|:    ....||..:||:.||.|: ..|
Zfish   409 HVEER-AESKA--VAYNCVYWAESERAWSRQGCERAWSN----STHTECSCSHLSSFAVLM-SLY 465

  Fly   483 RANDLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCL 547
            ...|..|.:|||.           ||..|||   |.:||....|:..||...|:..:||.|::||
Zfish   466 PVQDTFELVLITR-----------VGLVLSL---LCLFLCILTFRFCRSIQGTRNSIHLHLSVCL 516

  Fly   548 QMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPP 612
            .:...|||.      .:....|.|.|..:...:.:..|..|.|||:.....::..|.|.......
Zfish   517 FIADLVFLC------GISSTHNQVACAIVAGLLHFFFLSAFCWMLLEGVQLYRMVVLVFHTTLKH 575

  Fly   613 RYILKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPSGYGLIFGVVLPVTLITVCN 677
            .|:.   .|.:.:|||...:.|:..|..|       .||........|..|:..:.||.||...|
Zfish   576 LYMY---AVGYGVPLVIVSISAIAFPKGY-------GTDRHCWLSLKYDFIWSFLAPVCLIIGLN 630

  Fly   678 LVIFVYVFYSISHSLSQSIHKNEKKMVVKQIR----LSIMLFFLLGLTWIFGIFAFMQ--AGVAF 736
            .::||...:.::...| |::.:..|:  :.||    .::....:||..||||.|.|.:  ..||.
Zfish   631 SLVFVITVWKLAEKFS-SLNPDLSKL--RTIRGFTVTAVAQLCVLGGMWIFGSFLFYEKVTQVAL 692

  Fly   737 SYLFCITATMQGFVMFIYFVLLDSTNRRLWVGL---ICPTKMELDVQKRTTELQSMTTSSTNYNS 798
             |||.|..::||.::||...||....|..:..|   ||..|     :|:.:|.     |::|::|
Zfish   693 -YLFVILNSLQGALIFIMHCLLSRQVREEYCKLITRICSLK-----KKKYSEF-----STSNHSS 746

  Fly   799 ----RSHQ 802
                ||.|
Zfish   747 QQPLRSDQ 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	11/39 (28%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	70/255 (27%)
LOC100536657	XP_005171094.1	EGF_CA	34..67	CDD:214542
		EGF_CA	81..122	CDD:284955
		EGF_CA	124..153	CDD:214542
		EGF_CA	162..196	CDD:214542
		GPS	422..467	CDD:197639	15/49 (31%)
		7tm_4	473..706	CDD:304433	73/266 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900