DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11318 and adgre5

DIOPT Version :9

Sequence 1:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_031754104.1	Gene:	adgre5 / 100490425	XenbaseID:	XB-GENE-952950	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	168/790 - (21%)
Similarity:	277/790 - (35%)	Gaps:	256/790 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 PVTREC------RVKDNRANWESTEHWDPVVCLRRFREHTISGDLNSLHDDVLEGRRRTNDTQGR 166
            |.:.:|      |.|||..  |.|:.:.|          |.:.:.|.. ||:.|.:..||.. |.
Frog    96 PGSYQCQCESGYRRKDNTT--EFTDEFTP----------TDNKEQNKC-DDINECKELTNPC-GP 146

  Fly   167 REMTGIMRNMFR---QRGGNLLPADVHMTGQMFGALMQQDKDATVSVDLVSVCKE----IMSCDS 224
            :.:.......|:   |.|              :..|:|.|...|..|    ||||    ..||||
Frog   147 KSVCNNKPGFFKCSCQDG--------------YTDLLQNDTAHTQCV----VCKEGDGDKKSCDS 193

  Fly   225 KVLRLSAQLNATNSLLSQFESYMDALPEQLVPKDRCGKVVAKPTSDEAETATTGVETYNFSDIGV 289
            .               ..|:..:|.....|.|  .|.::|    :|.::.              :
Frog   194 N---------------DSFQCALDDFISSLTP--LCAQLV----NDHSKK--------------I 223

  Fly   290 QALITGNISVFFANPECDRITGLAIFSAPGDQ---RKTSASGFWYRFIRFSEDLAKVKEESNLET 351
            |.|:             |::.|  |||....|   .:..::|   :.::.:|.||:.....|.|.
Frog   224 QQLL-------------DQLNG--IFSRMSRQSLEERLKSTG---KVLKQAERLARNLSRLNHEN 270

  Fly   352 AAFLPENLWRQVKSRGATYLIFKVYAHDALFVETSLQRTRK--PRSKVISIS------------- 401
            ......|  ||::                       .||:|  .||::||:.
Frog   271 ITLTSNN--RQIE-----------------------LRTQKGSRRSRMISVKSKRSRLEVDPNTA 310

  Fly   402 ----------------------------IPGLRSNYLSLPLP----FLLRNENLRNPDSKAFSI- 433
                                        :.|..|:.:.|..|    ||.|.:......|..|.:
Frog   311 AADSTDDFPLVGFLEYNSLAPLLEGAPIVGGSNSSPVILISPVISTFLSREDTSSLNQSIRFRLE 375

  Fly   434 -----------GSGCGYWNYE--TWSTEGVSTESSSDLLKDAIIECHTNHLTQFAFLVGGSYRAN 485
                       .:.|.:|:.:  .|||.|..|..||    :....|...|:|.||.|:.    .|
Frog   376 HTAINSTIDPNRTTCAFWSQDDTAWSTAGCITLESS----EQETNCSCVHMTSFAILMA----VN 432

  Fly   486 DLGEEILITPINEKVLDIISIVGCSLSLLGILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQMM 550
            ::.|.:...|     |.:|:::|.|:|::.:....:|....:|.|...:| :..||||::.|...
Frog   433 NVEEIVKSWP-----LTLITLIGLSVSIICLSLCIITFIFCRSLRGTRNT-IHTHLCLSLFLGHC 491

  Fly   551 LFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVTVIGIERPPRYI 615
            .|:.        .:..:.|.|.|..:...:....|..|.||.:.....:...|.|.......||:
Frog   492 TFLL--------GINAHNNPVACSVVAGLLHTFYLASFCWMSLEGVELYLMLVQVFNTHLKKRYL 548

  Fly   616 LKAAIVAWLLPLVPTLLVALIDPDSYVPSAAQLSTDTGICYPSGYG------------LIFGVVL 668
            |   ::.:.:||.   :||:        ||:        .||:|||            .|:..:.
Frog   549 L---LIGYGVPLA---IVAI--------SAS--------VYPAGYGTQLHCWLSLERSFIWSFMG 591

  Fly   669 PVTLITVCNLVIFVYVFYSISHSLSQSIHKNEKKMVVKQIRL-SIMLFFLLGLTWIFGIFAFMQA 732
            ||.:|.:.|..|||...:.::..:||...:.||...::.:.: ::....:||..|:||...|..:
Frog   592 PVCVILLVNSGIFVLTVWKLAEKMSQINPEMEKYRRIRSLTVTAVAQLSILGCCWVFGFLQFSSS 656

  Fly   733 GVAFSYLFCITATMQGFVMFIYFVLLDSTNR---RLWVGLI----CPTKMELDVQKRTTELQSMT 790
            .:.|:|.|.|..|:||..:||...|:....|   ..|:..|    .||..|.     |:..||.|
Frog   657 SLFFAYAFSILNTLQGLQIFILHCLMSKKVRADYSRWLSAIARCKAPTYSEF-----TSTSQSQT 716

  Fly   791 TSSTNYNSRS 800
            .:.......|
Frog   717 QTRNKLKDSS 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11318	NP_651842.3	GPS	437..475	CDD:280071	12/39 (31%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	63/262 (24%)
adgre5	XP_031754104.1	EGF_CA	21..>53	CDD:311536
		EGF_CA	75..115	CDD:311536	6/20 (30%)
		EGF_CA	133..167	CDD:214542	8/48 (17%)
		GAIN	<241..356	CDD:406802	20/142 (14%)
		GPS	387..431	CDD:197639	15/51 (29%)
		7tmB2_CD97	440..699	CDD:320554	70/294 (24%)
		TM helix 1	443..467	CDD:320554	6/23 (26%)
		TM helix 2	476..497	CDD:320554	7/29 (24%)
		TM helix 3	507..529	CDD:320554	4/21 (19%)
		TM helix 4	547..563	CDD:320554	6/29 (21%)
		TM helix 5	582..605	CDD:320554	6/22 (27%)
		TM helix 6	632..654	CDD:320554	5/21 (24%)
		TM helix 7	658..683	CDD:320554	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I4935
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050