DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15553 and MFSD14B

DIOPT Version :9

Sequence 1:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_115947.2	Gene:	MFSD14B / 84641	HGNCID:	23376	Length:	506	Species:	Homo sapiens

Alignment Length:	479	Identity:	102/479 - (21%)
Similarity:	168/479 - (35%)	Gaps:	143/479 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IYQACTVIFQYNETDCKLLDSKNTTTEIQAIETELQDYVANMFLTRTLFESIMPAICGL---FVG 107
            :|.|..|||      .:.......||.:..:..|  .:..:.||...|.:.:...:..|   .:|
Human    45 VYHAAIVIF------LEFFAWGLLTTPMLTVLHE--TFSQHTFLMNGLIQGVKGLLSFLSAPLIG 101

  Fly   108 SWSDQYGRKPLMIVSLVGFSASALISSIICWLSSYYMVNPWWYTLAAVPHSVLGGWCVFSV---A 169
            :.||.:||||.:: ..|.|:         |:......::|||| .|.:  ||.|   ||||   .
Human   102 ALSDVWGRKPFLL-GTVFFT---------CFPIPLMRISPWWY-FAMI--SVSG---VFSVTFSV 150

  Fly   170 AFCFITDTTDMKTRPYRMIFMEIILFVALTSGSLLSSFVYAATSSAFVQSLSCLIVIIATLFIIF 234
            .|.::.|.|....|.....::......:|.|...:.:::.|:...:.|..::.::.::...||:.
Human   151 IFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILV 215

  Fly   235 YLPESLGMSPEEDEIPEKEKNVVVTVLDHKNKTNEISAEAEKTENCDDPPKYESPEKPLEDKVEK 299
            .:||||         |||.:              .:|..|:.:....||
Human   216 AVPESL---------PEKMR--------------PVSWGAQISWKQADP---------------- 241

  Fly   300 AGLFSIKHV-KDMFSTCFKKRENNAHTIIWLVTLAGFVSIFVADGVMTVNYLFVRQQFHFTVRDF 363
              ..|:|.| ||              :.:.|:.:..|:|.....|..:..:|::||...|.
Human   242 --FASLKKVGKD--------------STVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFG---- 286

  Fly   364 TIFETFSQSVPMLGAVLGILILRKFFGLSVVA-LALLSLLSEVAAN-----IARGFAYL------ 416
                  |..:....|::||        ||:|| .|.||:|.....|     :..||..|
Human   287 ------SVKIAAFIAMVGI--------LSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYG 337

  Fly   417 ----SWHLYLSVVLGIFRSIQGPMFRTIVSNIVPPSDTGKLFAIGNILQSFAPFVAAPLYTAIYK 477
                :|.::.:..:....||..|....:||........|               ||..:.|.|
Human   338 FGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQG---------------VAQGIITGI-- 385

  Fly   478 ESLASNPGGFNFLSAAFYGLAFIL 501
                  .|..|.|..|.||..|.:
Human   386 ------RGLCNGLGPALYGFIFYM 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	81/395 (21%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	34/147 (23%)
MFSD14B	NP_115947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MFS	48..450	CDD:119392	101/476 (21%)
		MFS_1	49..394	CDD:284993	96/464 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D763423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820