DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15553 and Slc46a3

DIOPT Version :9

Sequence 1:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001343931.1	Gene:	Slc46a3 / 71706	MGIID:	1918956	Length:	460	Species:	Mus musculus

Alignment Length:	524	Identity:	109/524 - (20%)
Similarity:	203/524 - (38%)	Gaps:	128/524 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YIEPVLFMLIFSHMLSGTVMRNQLIYQAC-------TVIFQYNETDCKLLDSKNTTTEIQAIETE 79
            :|||.:.:..|:..|: ..:..|.:|:..       |.....|.::|    .:|.::.|.|...|
Mouse     5 FIEPAILLNAFAMTLT-IPLTAQYVYRRIWEETGNYTFASNSNGSEC----DQNKSSSIFAFREE 64

  Fly    80 LQDYVANMFLTRTLFESIMPAICGLF-VGSWSDQYGRKPLMIVSLVGFSASALISSIICWLSSYY 143
            :|. .|::|..:....:::|.:...| :.:.||.:|||..|::|.:|   |...::.:|.:|  |
Mouse    65 VQK-KASLFNLQVEMSALIPGLVSTFMLLASSDNHGRKLPMVLSSLG---SLGTNTWLCMMS--Y 123

  Fly   144 MVNPWWYTLAAV-PHSVLGGWCVFSVAAFCFITD-TTDMKTRPYRMIFMEIILFV-----ALTSG 201
            ...|....:|:. ..::.|.:..|..|.|.:|.| ..:.|.|..|:..::.:|.|     .|:||
Mouse   124 FDLPLQLLIASTFIGALFGNYTTFWGACFAYIVDQQKEYKHRIIRIAILDFMLGVVTGLTGLSSG 188

  Fly   202 SLLSSFVYAATSSAFVQS--LSCLIVIIATLFIIFYLPESLGMSPEEDEIPEKEKNVVVTVLDHK 264
                   |......||.|  ::.:::|:...:|:|:|         .|.|.|....:|
Mouse   189 -------YFIRELGFVWSYFITAMVLIVNLAYILFFL---------NDPIKESSSQIV------- 230

  Fly   265 NKTNEISAEAEKTENCDDPPKYESPEKPLEDKVEKAGLFSIKHVKDMF---STCFKKRENNAHTI 326
                        |.:|                        |:.:||:|   ...||...:....:
Mouse   231 ------------TMSC------------------------IESLKDLFYRTYMLFKNGSSKRQAL 259

  Fly   327 IWLVTLAGFVSIFVADGVMTVNYLFVRQQFHFTVRDFTIFE---------------TFSQSVPML 376
            :.|:.....:..||..|:..:               ||::|               :...||..|
Mouse   260 LCLLIFTLVIYFFVIIGISPI---------------FTLYELGPPLCWNEVYIGYGSALGSVSFL 309

  Fly   377 GAVLGILILRKFFGLSVVALALLSLLSEVAANIARGFAYLSWHLYLSVVLGIFRSIQGPMFRTIV 441
            .:.|||.:..  :.|..:.:|.:.:.:.:.......|...:..::|..:..||..:...:.|:::
Mouse   310 SSFLGIWLFS--YCLKDIHIAYIGIFTTMVGMTLAAFTRTTLMMFLVRIPFIFTIMPLSVLRSML 372

  Fly   442 SNIVPPSDTGKLFAIGNILQSFAPFVAAPLYTAIYKESLASNPGGFNFLSAAFYGLAFI------ 500
            |.:|..::.|.|||....|::.|...:...|:.||..::|..||....|||....|..|
Mouse   373 SKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYSATVAWYPGFIFLLSAGLLVLPAISLCCVK 437

  Fly   501 LIGW 504
            .|||
Mouse   438 SIGW 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	78/400 (20%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	38/151 (25%)
Slc46a3	NP_001343931.1	MFS	3..437	CDD:391944	106/518 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4732
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010