DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15553 and slc46a1

DIOPT Version :9

Sequence 1:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_956579.1	Gene:	slc46a1 / 393255	ZFINID:	ZDB-GENE-040426-1012	Length:	481	Species:	Danio rerio

Alignment Length:	516	Identity:	98/516 - (18%)
Similarity:	193/516 - (37%)	Gaps:	141/516 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 IEPVLFMLIFSHMLSGTVMRNQLIYQACTVIFQYNET---DCKLLDSKNTTTEIQAIETELQDYV 84
            :|||:|:..||.:|...:. .|.::...:....||.|   .|      |.:|....::||::...
Zfish    45 VEPVMFLSTFSIVLQAPLC-TQYLWDRLSEDVGYNGTKTGGC------NASTVHDPLQTEVETLT 102

  Fly    85 ANMFLTRTLFESIMPAICGLF----VGSWSDQYGRKPLMIVSLVGFSASALISSIICWLSSYYMV 145
            |:.    :|:.::...:.|||    :|||||:.||:.::|:..:|.:..|.:     :|:..|:.
Zfish   103 AHW----SLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAV-----YLTVMYLK 158

  Fly   146 NP-WWYTLAAVPHSVLGGWCVFSVAAFCFITDTTDMKTRPYRMIFMEIILFVALTSGSLLSS--- 206
            .| :|:.:..:...:.|.:.......|.::.||::..:|.:|:..:|..|.:|....|::..
Zfish   159 LPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWR 223

  Fly   207 ---------FVYAATSSAFVQSLSCLIVIIATLFIIFYLPESLGMSPEEDEIPEKEKNVVVTVLD 262
                     ::..||:            :.|.|:...::||::...|:
Zfish   224 RAQGYINPFWLVLATN------------LTAALYAYLFVPETVTPDPQ----------------- 259

  Fly   263 HKNKTNEISAEAEKTENCDDPPKYESPEKPLEDKVEKAGLFSIKHVKDMFSTCFKKRENNAHTII 327
                                                 |.|||.:|.:.:.............:.:
Zfish   260 -------------------------------------ARLFSTRHHQAVCRLYSSDAPPGRRSKL 287

  Fly   328 WLVTLAGFVSIFVADGVMTVNYLFVRQQFHFTVRDFTIFETFSQSVPML---------GAVLGIL 383
            ||..|..|:       |:||         |....|  ::..:..|.|:.         .|...:.
Zfish   288 WLYILCFFL-------VVTV---------HLGCSD--LYVLYELSAPLCWGPELIGYGSAAKHLA 334

  Fly   384 ILRKFFGLSVVA-------LALLSLLSEVAANIARGFAYLSWHLYLSVVLGIFRSIQGPMFRTIV 441
            .|....||..:.       :||:.|.|.:...:....|..:..::....|........|:.|:.:
Zfish   335 YLTSLTGLRAMQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKL 399

  Fly   442 SNIVPPSDTGKLFAIGNILQSFAPFVAAPLYTAIYKESLASNPGGFNFLSAAFYGLAFILI 502
            |.:|.|::.|.|||....::.....|::.::.|:|..:|.... ||.|:    :|.|.:||
Zfish   400 SKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLHFMK-GFPFV----FGAAILLI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	70/405 (17%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	32/158 (20%)
slc46a1	NP_956579.1	MFS	93..460	CDD:119392	84/461 (18%)
slc46a1	NP_956579.1	MFS_1	114..427	CDD:284993	70/401 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960