DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15553 and CG8008

DIOPT Version :9

Sequence 1:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	337/565 - (59%)
Similarity:	415/565 - (73%)	Gaps:	44/565 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKAS----LSQLKTLEWGRLFNMFYIEPVLFMLIFSHMLSGTVMRNQLIYQACTVIFQYNETDC 61
            :||||    |.:|:.|:|.::|.|||||||:|||:|||.||||:.|||:|||.|||||.|||:||
  Fly     2 VEKASNAFTLEKLRNLQWEKVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDC 66

  Fly    62 KLLDSKNTTTEIQAIETELQDYVANMFLTRTLFESIMPAICGLFVGSWSDQYGRKPLMIVSLVGF 126
            |.||.||.:.||.|||||||.||||:||.|||.|||:||.||||:|||||.||||||:|||::||
  Fly    67 KQLDVKNASAEINAIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGF 131

  Fly   127 SASALISSIICWLSSYYMVNPWWYTLAAVPHSVLGGWCVFSVAAFCFITDTTDMKTRPYRMIFME 191
            |||.|:.:.||.|||||:||||||.:||||||:|||.|||||||||||:|.||.|:|||||||||
  Fly   132 SASFLMMAAICELSSYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFME 196

  Fly   192 IILFVALTSGSLLSSFVYAATSSAFVQSLSCLIVIIATLFIIFYLPESLGMSPEED------EIP 250
            .:.|:.||||||||||||||..||....:|..||..|||||||::||||....|::      ...
  Fly   197 SLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANV 261

  Fly   251 EKE---KNVVVTVLD--------------------HKNKTNEISAEAEKTENCDD---------- 282
            |||   ..|.:|..|                    .|:|..|:...|....:.||
  Fly   262 EKECIDSKVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVERL 326

  Fly   283 PPKYESPEK-PLEDKVEKAGLFSIKHVKDMFSTCFKKRENNAHTIIWLVTLAGFVSIFVADGVMT 346
            |.|.|..:: ..|::.:||||||:.|::||.|||||:|:::|..||||||||.|:||||.|||||
  Fly   327 PQKAEERKRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMT 391

  Fly   347 VNYLFVRQQFHFTVRDFTIFETFSQSVPMLGAVLGILILRKFFGLSVVALALLSLLSEVAANIAR 411
            |.|||||::||:||||:|.|||.|..|||:||::|.|||||.|.||||.||||:..||:..|:|:
  Fly   392 VMYLFVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFSEILNNLAK 456

  Fly   412 GFAYLSWHLYLSVVLGIFRSIQGPMFRTIVSNIVPPSDTGKLFAIGNILQSFAPFVAAPLYTAIY 476
            |||.:.||:||||.||:||||.|||.||||||||||||.||:|:|.|:||||||||||||||.||
  Fly   457 GFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIY 521

  Fly   477 KESLASNPGGFNFLSAAFYGLAFILIGWVMRIKFKHQKFYAKTLK 521
            |.||.:.||.|||:|:..|.|:|:.||:|:|||:::::.|||.||
  Fly   522 KRSLTTYPGLFNFVSSFLYLLSFVFIGYVLRIKYRYKQHYAKVLK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	240/412 (58%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	101/141 (72%)
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	260/445 (58%)
		MFS_1	101..>261	CDD:284993	106/159 (67%)
		MFS_1	375..>558	CDD:284993	124/182 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458926
Domainoid	1	1.000	92	1.000	Domainoid score	I7560
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4421
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	1	0.900	-	-		OOG6_153665
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
	11	10.800