DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15553 and CG31321

DIOPT Version :9

Sequence 1:	NP_651841.3	Gene:	CG15553 / 43677	FlyBaseID:	FBgn0039817	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_731899.1	Gene:	CG31321 / 318681	FlyBaseID:	FBgn0051321	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	143/563 - (25%)
Similarity:	244/563 - (43%)	Gaps:	97/563 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WGRLFNMFYIEPVLFMLIFSHMLSGTVMRNQLIYQACTVIFQYNE-------------TDCKLLD 65
            | |..:...|||..|....:.:.:...|:|..:.:||.|...||:             .:|...|
  Fly    31 W-RYRHYLVIEPFFFFYFMASVFNAVAMQNFPLDKACRVNLGYNKIVCDTMLDKSELGIECDDFD 94

  Fly    66 SKNTT-------------------TEIQAIETELQDYVANMFLTRTLFESIMPAICGLFVGSWSD 111
            .:|||                   |..:| |.|.|...|::...|....:|.|.|..||.|.|:|
  Fly    95 FENTTQGATPDLADLVIGATGFNYTVCKA-ELEAQILAADVSGKRAPMAAIFPLIVLLFAGGWAD 158

  Fly   112 QYG-RKPLMIVSLVGFSAS---ALISSIICWLSSYYMVNPW---WYTLAAVPHSVLGGWCVFSVA 169
            :|. |||.||:.::|.:.|   .:||||      ::...|.   .|..|.|| ::.||.....:|
  Fly   159 RYNKRKPCMIMPIIGEALSFTCQIISSI------FFESLPMEFGAYCEAIVP-ALFGGLTFCLMA 216

  Fly   170 AFCFITDTTDMKTRPYRM----IFMEIILFVALTSGSLLSSFVYAATSSAFVQSLSCLIV--IIA 228
            .:.:||..|..:.|.:|.    :|:..:.|:    |..:|..::  |:..:..|.:..||  :||
  Fly   217 IYSYITIATPEEDRVFRFGIFAMFVTGVPFI----GQPISGVLF--TTLGYTWSFASAIVFQLIA 275

  Fly   229 TLFIIFYLPE----------SLGMSPEEDEIPEKEKNV-----VVTVLD----HKNKTNEISAEA 274
            ..:|||::.|          :....|....:|.|::..     ..|.||    :||...:::.:.
  Fly   276 IFYIIFFIKEVKTTPTTSTTANEPPPLPTSLPPKQQGADNMAYETTNLDELQGNKNVNFQLTPQM 340

  Fly   275 EKTENCDDPPKYE--SPEKPLEDKVEKAGLFSIKHVKDMFSTCFKKRENNAHTIIWLVTLAGFVS 337
            |        ||.|  .|::.|..:     ||....|.|.......||.||...::.|:..|.|::
  Fly   341 E--------PKVEVVPPKRSLLKE-----LFDPTLVLDCIRFPLVKRPNNGRMLLILLLCAYFLT 392

  Fly   338 IFVADGVMTVNYLFVRQQFHFTVRDFTIFETFSQSVPMLGAVLGILILRKFFGLSVVALALLSLL 402
            :....|.....|.|..::..:...||:|:.|.|....::|..:|..||.|...:|...:.:||.|
  Fly   393 VGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFIGTAILSKLLKVSDSMIGMLSAL 457

  Fly   403 SEVAANIARGFAYLSWHLYLSVVLGIFRSIQGPMFRTIVSNIVPPSDTGKLFAIGNILQSFAPFV 467
            |.|.:.:...|:..:...|::.|:.:|.|::....:||.|:||...:..|:::|..|.:..|.|:
  Fly   458 SIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFI 522

  Fly   468 AAPLYTAIYKESLASNPGGFNFLSAAFY---GLAFILIGWVMR 507
            ..|:::.|||.::.|.||........||   .|.|::..:::|
  Fly   523 FPPIFSEIYKSTVDSFPGAIWLFGEIFYIPNVLVFVVCYFLLR 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15553	NP_651841.3	MFS_1	96..469	CDD:284993	106/406 (26%)
CG15553	NP_651841.3	MFS	97..239	CDD:304372	47/164 (29%)
CG31321	NP_731899.1	MFS	141..>271	CDD:119392	40/142 (28%)
		MFS_1	143..>271	CDD:284993	40/140 (29%)
		MFS	<379..559	CDD:119392	48/179 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458942
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900