Protein Alignment nkx6.1 and lab

DIOPT Version :10

• Sequence 1: NP_001002475.1
• Gene: nkx6.1 / 436748
• ZFINID: ZDB-GENE-040718-178
• Length: 312
• Species: Danio rerio
• Sequence 2: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 72/311 - (23%)
• Similarity: 104/311 - (33%)
• Gaps: 108/311 - (34%)

Zfish    37 PAYPLSSTGPASSTS--PTATSPNPGGI------PVSSPGIKTSSGLSALASAQQCAIATPHGIN 93
            |.:| .:..||:...  ..:.||| ||:      .|.|||..|||..||
  Fly   323 PQHP-QNQSPAAHQQHHQNSVSPN-GGMNRQQRGGVISPGSSTSSSTSA---------------- 369

Zfish    94 DILSRPSVACSPAGILSGLPRFSSLSP-------------PPPPGLYFSPSAAAVAVARYPKPLT 145
                  |....||...|..|..||..|             |..|.|   |::...::..|
  Fly   370 ------SNGAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKL---PASGIASMHDY----- 420

Zfish   146 ELPGRTPIF------WPGVMQSP----------------------HWRDARFACSPHQNSVLLD- 181
            ::.|:..:.      ..||...|                      ....|..|.|.|.|.:.:.
  Fly   421 QMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVGL 485

Zfish   182 -----------KDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQ 235
                       ........|..|:.:|:..|||.|...:||....|..:|.:|.:.|:|||:|||
  Fly   486 GSGSGLSSCSLSSNTNNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQ 550

Zfish   236 NRRTKWRKR-------------HAAEMASAK--KKQDSETERLKGASENED 271
            |||.|.:||             |:..:.|.|  ::|..:...|:..|:..|
  Fly   551 NRRMKQKKRVKEGLIPADILTQHSTSVISEKPPQQQQPQPPELQLKSQGSD 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nkx6.1	NP_001002475.1	Homeodomain	185..243	CDD:459649	23/57 (40%)
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	23/52 (44%)