Protein Alignment dco and YCK3

DIOPT Version :10

• Sequence 1: NP_524602.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Sequence 2: NP_011049.2
• Gene: YCK3 / 856860
• SGDID: S000000925
• Length: 524
• Species: Saccharomyces cerevisiae
• Alignment Length: 474
• Identity: 176/474 - (37%)
• Similarity: 244/474 - (51%)
• Gaps: 89/474 - (18%)

  Fly     5 VGNKYRLGRKIGSGSFGDIYLGTTI------NTG-----------EEVAIKLECIRTKHPQLHIE 52
            ||..|.:|.|||.||||.|:.|..|      .||           |.||||.|...:..|||..|
Yeast    10 VGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRDE 74

  Fly    53 SKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRID 117
            .:.|:.:.|.:|||...:.|.||.:|:::::||||||||||.:|.|:||:||..::|.|||.|:.
Yeast    75 FRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVAKQMIDRVR 139

  Fly   118 YIHSRDFIHRDIKPDNFLMG----LGKKG--------------NLVYIIDFGLAKKFRDARSLKH 164
            .||..|.|:|||||||||:.    :..:|              ||:|::|||:||::||.|:.:|
Yeast   140 AIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYRDPRTKQH 204

  Fly   165 IPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERI- 228
            |||||.|:|:|||||.|||||.|.||||||||||||:|..||..|:||||||||.|.:.|||:|
Yeast   205 IPYRERKSLSGTARYMSINTHFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIG 269

  Fly   229 -SEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDW-- 290
             :::||:...::|....|.:|..||.:.|.:.||:.|||.:|..|..:.........|..:||
Yeast   270 MTKQKLNPDDLLLNNAIPYQFATYLKYARSLKFDEDPDYDYLISLMDDALRLNDLKDDGHYDWMD 334

  Fly   291 ---------------NLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAAVA-AAAAASSHQQQQ 339
                           ||..:|.| ||:        .:|....:.|...:... ....|:..||.|
Yeast   335 LNGGKGWNIKINRRANLHGYGNP-NPR--------VNGNTARNNVNTNSKTRNTTPVATPKQQAQ 390

  Fly   340 HKVN-----AALGGGGGSAAQQQLQGGQTLAMLGGNGGGNGSQLIGGNGLNMD----------DS 389
            :..|     :.:.....|..:||    ..|..:..|     |:.|.....|:.          ||
Yeast   391 NSYNKDNSKSRISSNPQSFTKQQ----HVLKKIEPN-----SKYIPETHSNLQRPIKSQSQTYDS 446

  Fly   390 MAAT-NSSRPPYDTPERRP 407
            ::.| ||...||.:.:..|
Yeast   447 ISHTQNSPFVPYSSSKANP 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_524602.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	142/310 (46%)
YCK3	NP_011049.2	Protein Kinases, catalytic domain	13..320	CDD:473864	142/306 (46%)
		ROM1	361..>479	CDD:227709	23/114 (20%)