Protein Alignment dco and VRK2

DIOPT Version :9

• Sequence 1: NP_001263132.1
• Gene: dco / 43673
• FlyBaseID: FBgn0002413
• Length: 440
• Species: Drosophila melanogaster
• Sequence 2: NP_001123952.1
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 119/392 - (30%)
• Similarity: 184/392 - (46%)
• Gaps: 51/392 - (13%)

  Fly     6 GNKYRLGRKIGSGSFGDIYLGTTINTGEEVA---IKLECIRTKHPQLHIESKFYKTMQ------- 60
            ||::.||:|||||.||.|||....|..|:.|   :|:|  ..::..|..|.|||:.:.
Human    26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE--YQENGPLFSELKFYQRVAKKDCIKK 88

  Fly    61 -------GGIGIPRIIWCGS-----EG-DYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQM 112
                   ..:|||  ::.||     :| .|..||||.||..|:.: :..:..|...|||.|..:|
Human    89 WIERKQLDYLGIP--LFYGSGLTEFKGRSYRFMVMERLGIDLQKI-SGQNGTFKKSTVLQLGIRM 150

  Fly   113 ISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYREN--KNLTG 175
            :..::|||..:::|.|||..|.|:|. |..:.||:.|:||:  :|...:..|..|:||  |...|
Human   151 LDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLS--YRYCPNGNHKQYQENPRKGHNG 212

  Fly   176 TARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPW-QGLK--AANKRQKYERISEKKLSTSI 237
            |..:.|::.|.|:..|||.|:|.|||.::.:..|.||| |.||  .|.:..|...:.|  |..|:
Human   213 TIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDE--LPQSV 275

  Fly   238 VVLCKGFPS-----EFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGG 297
            :   |..||     |...:|.....:.:|::|:|..|:|:.......|| ..|:......:....
Human   276 L---KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLG-PLDFSTKGQSINVHT 336

  Fly   298 PRNPQAIQQAQDGADGQA--GHDAVAAAAAVAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQG 360
            | |.|.: .:|..|..|.  .|:.:......:..:|.|....:..|....:|.....|||:..:.
Human   337 P-NSQKV-DSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRR 399

  Fly   361 GQ 362
            .|
Human   400 RQ 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_001263132.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	100/306 (33%)
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	101/300 (34%)
		SPS1	29..421	CDD:223589	117/389 (30%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810