DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dco and Vrk2

DIOPT Version :9

Sequence 1:	NP_001263132.1	Gene:	dco / 43673	FlyBaseID:	FBgn0002413	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_081536.2	Gene:	Vrk2 / 69922	MGIID:	1917172	Length:	503	Species:	Mus musculus

Alignment Length:	298	Identity:	99/298 - (33%)
Similarity:	146/298 - (48%)	Gaps:	42/298 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GNKYRLGRKIGSGSFGDIYLGTTINTGEEVA---IKLECIRTKHPQLHIESKFY----------K 57
            ||::.||:.||||.||.|||....|...:.|   ||||  ..::..|..|.|||          |
Mouse    26 GNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLE--YQENGPLFSELKFYQRAAKRECIQK 88

  Fly    58 TMQ----GGIGIPRIIWCG----SEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMIS 114
            .:|    ..:|||.....|    ....|..||||.||..|:.|.: .:..|...|||.|..:|:.
Mouse    89 WIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLD-QNGGFKKLTVLQLGIRMLD 152

  Fly   115 RIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYREN--KNLTGTA 177
            .::|||..:::|.|||..|.|:.. ...:.||:.|:||:  :|...:..|..|:|:  |...||.
Mouse   153 VLEYIHENEYVHGDIKAANLLLDF-TNPDRVYLADYGLS--YRYCPNGNHKQYQEDPRKGHNGTI 214

  Fly   178 RYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGL---KAANKRQKYERISEKKLSTSIVV 239
            .:.|::.|.|:..|||.|:|.|||.::::..|.|||:..   ..|.:..|...:.|  |..|::
Mouse   215 EFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDE--LPESVL- 276

  Fly   240 LCKGFP-----SEFVNYLNFCRQMHFDQRPDYCHLRKL 272
              |..|     ||.|.||.:...:.:|.:|||..|:|:
Mouse   277 --KWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKI 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_001263132.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	97/296 (33%)
Vrk2	NP_081536.2	PKc_like	16..314	CDD:389743	99/298 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..395
		Interaction with MAP3K7. /evidence=ECO:0000250	392..503
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810