DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dco and csnk1db

DIOPT Version :9

Sequence 1:	NP_001263132.1	Gene:	dco / 43673	FlyBaseID:	FBgn0002413	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_998415.1	Gene:	csnk1db / 406533	ZFINID:	ZDB-GENE-040426-2385	Length:	409	Species:	Danio rerio

Alignment Length:	429	Identity:	277/429 - (64%)
Similarity:	317/429 - (73%)	Gaps:	52/429 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGI 65
            |||||||:|||||||||||||||||||.|:.||||||||||::|||||||||||.||.||||:||
Zfish     1 MELRVGNRYRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGI 65

  Fly    66 PRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIK 130
            |.|.|||:|||||||||||||||||||||||||:|||||||||||||||||:||||::|||||:|
Zfish    66 PTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVK 130

  Fly   131 PDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDD 195
            |||||||||||||||||||||||||:||||:.:||||||||||||||||||||||||||||||||
Zfish   131 PDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD 195

  Fly   196 LESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHF 260
            ||||||||||||||:|||||||||.||||||||||||:||.|.|||||:||||..||||||.:.|
Zfish   196 LESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRF 260

  Fly   261 DQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAA 325
            |.:|||.:||:||||||||.||:||||||||:||||..|..:...:.:...|.:..|....||..
Zfish   261 DDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGANRTAEEADRERRERDERMRHSRNPAARG 325

  Fly   326 VAAAA---------------AASSH------------QQQQHKVNAALGGGGG-SAAQQQLQGGQ 362
            :.||:               ..:||            .:::.||:..|..|.. :.:...|.|.|
Zfish   326 IPAASGRPRPTQDGAPPTPLTPTSHTANTSSPRPVTGMERERKVSMRLHRGAPVNVSSSDLTGRQ 390

  Fly   363 TLAMLGGNGGGNGSQLIGGNGLNMDDSMAATNSSRPPYD 401
                                    |.|..:|:.:..|:|
Zfish   391 ------------------------DTSRMSTSQNSIPFD 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_001263132.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	235/273 (86%)
csnk1db	NP_998415.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	235/273 (86%)
		TyrKc	10..273	CDD:197581	226/262 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..409		20/130 (15%)
		Autoinhibitory. /evidence=ECO:0000250	317..341		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590669
Domainoid	1	1.000	408	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1094
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	1	1.000	-	-		otm24870
orthoMCL	1	0.900	-	-		OOG6_100396
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.700