DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dco and kin-19

DIOPT Version :9

Sequence 1:	NP_001263132.1	Gene:	dco / 43673	FlyBaseID:	FBgn0002413	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001369852.1	Gene:	kin-19 / 175524	WormBaseID:	WBGene00002202	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	215/346 - (62%)
Similarity:	261/346 - (75%)	Gaps:	20/346 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRII 69
            |..||:|.||||||||||||:...:..|||||||||..|.:||||..|||.|:.:|||:|||.|.
Worm    12 VATKYKLIRKIGSGSFGDIYVSINVTNGEEVAIKLESNRARHPQLLYESKVYRILQGGVGIPHIR 76

  Fly    70 WCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNF 134
            |.|:|.:|||:||:|||||||||||||||||::||||:||||||.||:|:|.::|||||||||||
Worm    77 WYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHRDIKPDNF 141

  Fly   135 LMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESL 199
            |||:|:..|.:::||||||||:||:|:..||||||:|||||||||||||.|||||||||||:|||
Worm   142 LMGIGRHCNKLFLIDFGLAKKYRDSRTRTHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESL 206

  Fly   200 GYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRP 264
            ||||||||.|.|||||||||.|:||||:|||||::||:..||||||:||..||::.|.:.||:.|
Worm   207 GYVLMYFNRGTLPWQGLKAATKKQKYEKISEKKMTTSVEHLCKGFPAEFPMYLSYTRGLRFDESP 271

  Fly   265 DYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAAVAAA 329
            ||.:||:|||.||..|...|||.|||.:||       |..||:|  :.|..|.:.....|.|.:|
Worm   272 DYMYLRQLFRILFRTLNHQYDYTFDWTMLK-------QKAQQSQ--SSGVPGTNTTTQGATVPSA 327

  Fly   330 AAASSHQQQQHKVNAALGGGG 350
            .           |.|.:..||
Worm   328 G-----------VPAGVAPGG 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_001263132.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	193/273 (71%)
kin-19	NP_001369852.1	STKc_CK1_alpha	15..280	CDD:271030	187/264 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100396
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760