DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dco and CSNK1E

DIOPT Version :9

Sequence 1:	NP_001263132.1	Gene:	dco / 43673	FlyBaseID:	FBgn0002413	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_001885.1	Gene:	CSNK1E / 1454	HGNCID:	2453	Length:	416	Species:	Homo sapiens

Alignment Length:	426	Identity:	281/426 - (65%)
Similarity:	326/426 - (76%)	Gaps:	55/426 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGI 65
            ||||||||||||||||||||||||||..|.:||||||||||::||||||||||||||.||||:||
Human     1 MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGI 65

  Fly    66 PRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIK 130
            |.|.|||:|||||||||||||||||||||||||:|||||||||||||||||:||||::|||||:|
Human    66 PSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVK 130

  Fly   131 PDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDD 195
            |||||||||||||||||||||||||:||||:.:||||||||||||||||||||||||||||||||
Human   131 PDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD 195

  Fly   196 LESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHF 260
            ||||||||||||||:|||||||||.||||||||||||:||.|.|||||:||||..||||||.:.|
Human   196 LESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRF 260

  Fly   261 DQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAVAAAAA 325
            |.:|||.:||:||||||||.||:||||||||:||||..|||:.:.:
Human   261 DDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDR------------------- 306

  Fly   326 VAAAAAASSHQQQQHKVNAALGGGGGSAAQQQLQGGQTLAM-LGGNGGGNGSQLIGGNGLNMDDS 389
                      ::::|:....:|         ||:|..|.|: .|...|...::|     .:..:.
Human   307 ----------ERREHEREERMG---------QLRGSATRALPPGPPTGATANRL-----RSAAEP 347

  Fly   390 MAATNSSR--PPYDTP---------ERRPSIRMRQG 414
            :|:|.:||  |..:|.         ||:.|:|:.:|
Human   348 VASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRG 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dco	NP_001263132.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	236/273 (86%)
CSNK1E	NP_001885.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	236/273 (86%)
CSNK1E	NP_001885.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..416		22/126 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155505
Domainoid	1	1.000	406	1.000	Domainoid score	I709
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121695
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1127
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	1	1.000	-	-		otm41979
orthoMCL	1	0.900	-	-		OOG6_100396
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800