DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and PHO8

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_010769.3	Gene:	PHO8 / 852092	SGDID:	S000002889	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	528	Identity:	140/528 - (26%)
Similarity:	223/528 - (42%)	Gaps:	133/528 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 VKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDK 139
            ::..|::||  |:|.|:.||||.:::|..|.: .|:: :....::.|..|:. ..|.::|.:.|.
Yeast    59 LRSASHKKK--NVIFFVTDGMGPASLSMARSF-NQHV-NDLPIDDILTLDEH-FIGSSRTRSSDS 118

  Fly   140 QVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNGQQGRVQSVMEWAQKEGKRTGVVTTTRITHAT 204
            .|.|||..|||.....|::.||||:| ...:..|      :|:|.|:..|..||:|.|||||.||
Yeast   119 LVTDSAAGATAFACALKSYNGAIGVD-PHHRPCG------TVLEAAKLAGYLTGLVVTTRITDAT 176

  Fly   205 PAATYAHIYDRDWECDTEVPAESVGFHVDIARQLVENAPGNRFNVILGGG----------MSPMG 259
            ||:..:|: |..|:.|.      :..|     ||.|...|...::::|||          .||.|
Yeast   177 PASFSSHV-DYRWQEDL------IATH-----QLGEYPLGRVVDLLMGGGRSHFYPQGEKASPYG 229

  Fly   260 ILNA-SEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLM 323
            ...| .:.:..|.|..:......||.:|..:...:|..|.|:|                    .:
Yeast   230 HHGARKDGRDLIDEAQSNGWQYVGDRKNFDSLLKSHGENVTLP--------------------FL 274

  Fly   324 GLFRNNHITYSIAREAGE-PSLQEMTETALGILERGD----ESNGFVLLVEGGRIDQGHHMNYAR 383
            |||.:|.|.:.|.|:..| |||:|..:.|||.||:..    :||||.|:|||.|||...|.|...
Yeast   275 GLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPA 339

  Fly   384 AALHELYEFDLAIQAAV---NNTDPDETLILVTADHSHAVTFNGYALRGADILGT---------- 435
            :.:.|:..||.|.|..:   .|:| .||:::.|:||.     .|..:....:..:
Yeast   340 SQVREVLAFDEAFQYVLEFAENSD-TETVLVSTSDHE-----TGGLVTSRQVTASYPQYVWYPQV 398

  Fly   436 -ANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAA---PTYRHLAT 496
             ||:....:.:..:.:.:.:     :|....|:.:|.      :||...|:...   .|...|.|
Yeast   399 LANATHSGEFLKRKLVDFVH-----EHKGASSKIENF------IKHEILEKDLGIYDYTDSDLET 452

  Fly   497 VPRKDE----------------------THG--GEDVAVFAY---------------GPGSSLIR 522
            :...|:                      |||  ..||.::||               |...:...
Yeast   453 LIHLDDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEV 517

  Fly   523 GVFEQNYL 530
            |.|.:|:|
Yeast   518 GQFLENFL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	140/528 (27%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	137/518 (26%)
PHO8	NP_010769.3	PhoA	8..530	CDD:224699	140/528 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345751
Domainoid	1	1.000	140	1.000	Domainoid score	I1026
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1177
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm46490
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	11	10.790