DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp4 and alpi.2

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001020359.1	Gene:	alpi.2 / 574009	ZFINID:	ZDB-GENE-050626-142	Length:	521	Species:	Danio rerio

Alignment Length:	544	Identity:	212/544 - (38%)
Similarity:	292/544 - (53%)	Gaps:	59/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TQPPPLIRTLSAGGDIGPQFDVGKTKEPEDAE---FWHNVGLRQLEKTIKQAQRVKEDSYQKKAR 85
            ||...||...::.|     ||...:..||:.:   ||:......|..::......      .:|:
Zfish     4 TQALLLIGIFASAG-----FDGCFSVVPEEEKNPNFWYVKAKDSLHASLSMTFNT------HRAK 57

  Fly    86 NIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATA 150
            |:|:|:||||||||::|.|:.|||..|. .|||..|..|.||...::||||||:|:||||.||||
Zfish    58 NLILFLGDGMGISTVTAARVLKGQMNKK-TGEESVLAMDTFPYLALSKTYNVDQQMPDSAATATA 121

  Fly   151 IFSGSKTHYGAIGMDATRSKK---NGQQGRVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHI 212
            ...|.|.:||.:|:.|...::   :.:...|:|::..|:..||..|:|:|.|:.||:|||:|:|.
Zfish   122 YLCGVKANYGTLGLSAAAQREVCSSVKGNEVKSILHQAKMAGKSVGIVSTARVQHASPAASYSHT 186

  Fly   213 YDRDWECDTEVPAESV-GFHVDIARQLVENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEG 273
            .:|.|..|.|:.:|:| |...|||.||:.|..   .|||||||   |.|.        :||..|.
Zfish   187 PERGWYSDKELTSEAVAGGCQDIAVQLITNTD---INVILGGGRQYMFPR--------ETTDPEY 240

  Fly   274 PTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIARE 338
            .|.| .:|.|.|||..|||.:..|    ...|.|::....||..|.|:|||||......|.:.|:
Zfish   241 STVT-GSRKDKRNLVDEWLKNRKN----AQYVWNKQQFDAVNEDKTDYLMGLFEPKDTRYELERD 300

  Fly   339 AG-EPSLQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNN 402
            .. :|||.||.|.|:.||.:  ..|||.|.|||||||.|||...|:.||.|..|||.:|:.|...
Zfish   301 PKMDPSLTEMVEKAIKILRK--NPNGFYLFVEGGRIDHGHHAGQAKYALTEAVEFDNSIERAGQL 363

  Fly   403 TDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSR 467
            |...:||.:|||||||..:|.||:.||..:||.:.:..::...|...: |.|||||  .:.|.:|
Zfish   364 TSELDTLSVVTADHSHVFSFGGYSYRGNPVLGVSYAKGEDGKSFTNAL-YGNGPGY--QITNGTR 425

  Fly   468 PQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAY 532
            |..:.::           .....|...|.||...||||.||||:||.||.:.|..||.||:|:.:
Zfish   426 PDVNESV-----------SGRDDYLQQAAVPLDSETHGSEDVAIFAKGPMAHLFHGVQEQSYIPH 479

  Fly   533 VMSYAGCLGPAKDFDDSCEDHKDG 556
            .|::|.|:.|..|    |:.|..|
Zfish   480 AMAFAACIEPYSD----CQLHDSG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	193/481 (40%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	194/463 (42%)
alpi.2	NP_001020359.1	Alk_phosphatase	56..487	CDD:278666	194/463 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760