DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and alpi.1

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001014375.1	Gene:	alpi.1 / 541539	ZFINID:	ZDB-GENE-050327-78	Length:	532	Species:	Danio rerio

Alignment Length:	549	Identity:	222/549 - (40%)
Similarity:	297/549 - (54%)	Gaps:	61/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CLVILGFLLGSLVAFSWAGVTTQPPPLIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEK 67
            ||| .|...|:|:....|        |:...|...|...:::       :|..:|::...|.|:.
Zfish     2 CLV-YGRAPGALLLLLLA--------LVLNTSCSLDSAAEWE-------KDPAYWNDQARRTLQT 50

  Fly    68 TIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMA 132
            .:....||      .:|:|||:|:|||||:||:||.||.:|| ::...|||..|..|.||...::
Zfish    51 ALTLPLRV------NRAKNIILFVGDGMGVSTVSAARILRGQ-MEGQSGEETILAMDTFPYLALS 108

  Fly   133 KTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMD--ATRSKKNGQQG-RVQSVMEWAQKEGKRTGV 194
            |||.|||||.|||.||||...|.|.:...:|:.  |...:.|...| .|.||:..|:.:||..|:
Zfish   109 KTYCVDKQVADSASTATAYHCGVKANAKTVGLSAKAVAYECNTTFGNEVFSVLHRAKAQGKSVGI 173

  Fly   195 VTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQLVENAPGNRFNVILGGG--- 254
            |||||:.||:|||.|||...|.|..|.:||:|:  .|.. |||.|||.|..   .:||||||
Zfish   174 VTTTRVQHASPAAAYAHSVSRKWYSDADVPSEARRQGCK-DIATQLVTNTD---IDVILGGGRMY 234

  Fly   255 MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKV 319
            |:|.|..: .|..::..:|      .|.|.:||...||  :|........|.|::....|:||..
Zfish   235 MTPKGTPD-PEYSSSSHKG------DRKDKKNLINVWL--NARKGRNAQYVWNKEQFNAVDVKTT 290

  Fly   320 DHLMGLFRNNHITYSIAR-EAGEPSLQEMTETALGILERGDESNGFVLLVEGGRIDQGHHMNYAR 383
            |.|||||....:.:.:.| ...:||:.:|||.|:.||.:..:  ||.|.|||||||.|||...|:
Zfish   291 DCLMGLFEPKDMRFEVFRNRTRDPSIVDMTEKAIQILSKNPK--GFFLFVEGGRIDHGHHDGVAK 353

  Fly   384 AALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYE 448
            .||.|...||.|||.|...|...:||.:|||||||..||.|...||..|.|.|....::| :.|.
Zfish   354 LALTETIMFDRAIQRASELTSESDTLTVVTADHSHVFTFGGKTPRGNPIFGLAPKQAEDD-LPYT 417

  Fly   449 TISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFA 513
            :|.||||||| ||: |.:|...|     .|.::..|      |:..|.||.:.|||||||||::|
Zfish   418 SILYANGPGY-DHV-NGTRGNVS-----VLDYYDEE------YKQQAAVPLESETHGGEDVAIYA 469

  Fly   514 YGPGSSLIRGVFEQNYLAYVMSYAGCLGP 542
            .||.:.|..||.||||:|:.|:||.||.|
Zfish   470 KGPMAHLFHGVKEQNYVAHAMAYAACLEP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	204/482 (42%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	203/464 (44%)
alpi.1	NP_001014375.1	PhoA	46..493	CDD:224699	205/482 (43%)
alpi.1	NP_001014375.1	Alk_phosphatase	61..496	CDD:278666	203/464 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760