DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and phu

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	221/585 - (37%)
Similarity:	312/585 - (53%)	Gaps:	74/585 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGFLLGSLVAFSWAGVTTQPP-----PLIRTLSAGGD-IG--------PQ--FDVGKTKEPEDAE 55
            |.|.||..|..| .|.::...     |:...:..|.: ||        ||  ||..:::| ..||
  Fly     5 LFFFLGLSVLVS-GGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVFDAVRSEE-RYAE 67

  Fly    56 FWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEET 120
            :|..:..:.|::.::...|:.    .:.|||:::||||||.|.||:|||:|.|       |||:.
  Fly    68 YWQGLAAQTLDQQLESKLRLN----TQLARNVMLFIGDGMSIPTITAGRVYLG-------GEEKQ 121

  Fly   121 LVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNGQ-----QGRVQS 180
            ..|:.||..|::|||..:.||.|||.||||...|.|.:||.||:.|....|:.|     ...|.|
  Fly   122 FAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSS 186

  Fly   181 VMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAES--VGFHVDIARQLVENAP 243
            :..||||:|..||:||||.:|||:||..|||:.:|:||.|.||..::  .....|.|.||:.:..
  Fly   187 IAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSPV 251

  Fly   244 GNRFNVILGGGMS---PMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALV 305
            |.:.|||:|||..   |.|:.::|....           .|.|.|||..||...|.|..   ..|
  Fly   252 GQKLNVIMGGGRENFLPKGVTDSSGAPG-----------RRLDGRNLIDEWKNQHTNSA---QYV 302

  Fly   306 HNRKDLLNVNVKKVDHLMGLFRNNHITYSI-AREAGEPSLQEMTETALGILERGDESNGFVLLVE 369
            .||::|||:: .....::|||...|:.|.: |..|.:|:|:||.::|:.||||.....|:.|.||
  Fly   303 ENRRELLNLS-NHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVE 366

  Fly   370 GGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILG 434
            |||||.|||...|..|:.|..|||.|::.|.::|..|:|||:|::||||.::..||:.|..||.|
  Fly   367 GGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFG 431

  Fly   435 TANSHEKNDPMFYETISYANGPGYWDHLANDS---RPQNSSNMWMPLKHFTAEERAAPTYRHLAT 496
            ..:.....|.:.|.|:||||||||..:...:.   |.:|...:.|..|.|...          :|
  Fly   432 INDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFP----------ST 486

  Fly   497 VPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKDGQKDRP 561
            ||.:.|||||:||||||.||.:.|..|||||:::.:.:.||.||...    :.|.|  .|...||
  Fly   487 VPLESETHGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDR----NMCVD--GGVARRP 545

Fly 562 561
Fly 546 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	193/487 (40%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	193/469 (41%)
phu	NP_649897.4	PhoA	71..524	CDD:224699	193/488 (40%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	192/468 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466677
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800