DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp4 and alpl

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_957301.2	Gene:	alpl / 393982	ZFINID:	ZDB-GENE-040420-1	Length:	561	Species:	Danio rerio

Alignment Length:	513	Identity:	222/513 - (43%)
Similarity:	298/513 - (58%)	Gaps:	44/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GKTKE--PED---AEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRI 105
            ||||.  ||.   .::|.:...|.|:..:|     .::..:..|:|||:|:|||||:.|::|.||
Zfish    50 GKTKVQFPEQEKRPDYWRDFAQRSLKDALK-----LQELNKNIAKNIILFLGDGMGVPTVTAARI 109

  Fly   106 YKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMD--ATR 168
            .||| |....|||..|..|.||:..::||||.:.|||||||||||...|.|.:.|.:|:.  |.|
Zfish   110 LKGQ-LSGQNGEETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVR 173

  Fly   169 SKKNGQQG-RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHV 232
            |:.|..|| .|.|:::||:..||..|:|||||:.||||:|.|||..||||..|.::|.|::....
Zfish   174 SQCNTTQGNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALQSGC 238

  Fly   233 -DIARQLVENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHA 296
             ||||||.||.|.  .|||:|||...|...|..:|:   :.|..:...||.|.|||..||:
Zfish   239 KDIARQLFENIPD--INVIMGGGRRSMYPKNTPDVE---YPGDKKQNGTRKDGRNLVGEWI---- 294

  Fly   297 NDTVPPA---LVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAREA-GEPSLQEMTETALGILER 357
             |.|...   .|.|:||||::|...||:|:|||....:.|.:.|.. .:|||.||.:.|:.||::
Zfish   295 -DRVKEKRGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKK 358

  Fly   358 GDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTF 422
            .:  .||.|||||||||.|||...|:.||||..|.|.||..|...|...:||.:|||||||..:|
Zfish   359 NE--RGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFSF 421

  Fly   423 NGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERA 487
            .||..||..|.|.|.:....|...:..|.|.||||:  .|.|.:| :|.|.:.....::.|:
Zfish   422 GGYTPRGNSIFGLAPTLSDVDQKPFTAILYGNGPGF--KLVNGAR-ENVSTVDYQQNNYQAQ--- 480

  Fly   488 APTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKD 545
                   :.||.:.|||||||||:|:.||.:.|:.||.||:|:.:||:||.|:|..||
Zfish   481 -------SAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQHYIPHVMAYAACIGQNKD 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	207/481 (43%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	208/463 (45%)
alpl	NP_957301.2	Alk_phosphatase	88..526	CDD:278666	208/463 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.660