DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and Alp10

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	192/508 - (37%)
Similarity:	278/508 - (54%)	Gaps:	45/508 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |..|..|||:.....|...:...:::.|:    :|:|:|:|:||||.:.||:|.|.:.|.
  Fly    45 EELDTRFWHDKAQSILADKLAGHKKLNEN----RAKNVILFLGDGMSVHTIAATRAFMGD----- 100

  Fly   115 YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKN---GQQG 176
              ..:.:.|:.||..|::|||.|:::.||||.||||..:|.|.:||.||::|...:.:   ....
  Fly   101 --SNKQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSS 163

  Fly   177 RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAE--SVGFHVDIARQLV 239
            .|||:.:|||:.||..|:|||.|:|||:||..|||:.:|:||.|.|:.:.  |...:.|||||||
  Fly   164 HVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLV 228

  Fly   240 ENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPAL 304
            |...|....||:|||.|  ...:.|:...|...|      .|.|.|:|.::|.............
  Fly   229 EWPVGQELRVIMGGGRS--YFRDQSQHDETGVSG------LRTDGRDLISDWREIKKQQGAEGKY 285

  Fly   305 VHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAR-----EAGEPSLQEMTETALGILERGDESNGF 364
            |.:.|.|...::.|.|:|:|||..:|:.|...|     |..||||.:|||.|:.:|.:.:|  |:
  Fly   286 VWSLKGLKETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEE--GY 348

  Fly   365 VLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRG 429
            .|.||.||||..||...|..||.:..||..|::.|...||.::|||:||:||||.::.|||..|.
  Fly   349 FLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRR 413

  Fly   430 ADILGTANSHEKNDPMFYETISYANGPGYWD-HLANDSRPQNSSNMWMPLKHFTAEERAAPTYRH 493
            .:||..| .:..:|.:.:..:|||||||:.| :...|.|        :.|.|   .:..:..:..
  Fly   414 QNILSLA-PNLADDELPFTILSYANGPGFDDTYSTKDGR--------IDLSH---ADTTSAEFEF 466

  Fly   494 LATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGP-AKD 545
            .||||...||||.|||.|||.||...|..|.:||:.:..:|:||..:|| |||
  Fly   467 QATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPFAKD 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	179/484 (37%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	179/466 (38%)
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	180/486 (37%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	179/464 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466678
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800