DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp4 and Alpg

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_038940610.1	Gene:	Alpg / 367308	RGDID:	1565100	Length:	533	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	218/506 - (43%)
Similarity:	280/506 - (55%)	Gaps:	46/506 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHG 114
            |.|:..||:    ::.::.:..|:::|  ..:..|:|:|||:|||||:.|::|.||.|||...|
  Rat    26 EEENPAFWN----QKAKEALDVAKKLK--PIRTSAKNLIIFLGDGMGVPTVTATRILKGQLGGH- 83

  Fly   115 YGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATR--SKKNGQQG- 176
            .|.|..|..|.||.|.::||||||:|||||||||||...|.|.:|..||:.|..  ::.|...|
  Rat    84 LGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGN 148

  Fly   177 RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESV--GFHVDIARQLV 239
            .|.|||..|:|.||..||||||.:.||:||.||||..:.||..|..:...::  |.. |||.||:
  Rat   149 EVFSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNCDWYSDAHMATAALQEGCK-DIAMQLI 212

  Fly   240 ENAPGNRFNVILGGG---MSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVP 301
            .|..   .:||||||   |.|.|..:..      :.|......||.|.:||..:|||.|..
  Rat   213 SNMD---IDVILGGGRKFMFPKGTPDPE------YSGNRAQSGTRLDGQNLVQKWLAKHQG---- 264

  Fly   302 PALVHNRKDLLNVNV-KKVDHLMGLFRNNHITYSIARE-AGEPSLQEMTETALGILERGDESNGF 364
            ...|.||.:|:..:. ..|.||||||..|.:.|.|.|: ..:|||.||||.|:.:|.|..:  ||
  Rat   265 ARYVWNRTELIQASQDSAVTHLMGLFEPNDMKYDIYRDPTQDPSLAEMTEVAVHLLSRNPK--GF 327

  Fly   365 VLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRG 429
            .|.||||.||.|||.:.|..||.|...||.|:..|...|...:|:|||||||||..:|.||..||
  Rat   328 YLFVEGGHIDHGHHESIAYRALTEAVMFDSAVDKANKLTSEKDTMILVTADHSHVFSFGGYVPRG 392

  Fly   430 ADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHL 494
            ..|.|...|....|...:.:|.|.|||||  .|...:||.           .|.:|...|.||..
  Rat   393 TSIFGLGASFNALDGRPFTSILYGNGPGY--KLEKGTRPD-----------VTDKESRDPKYRQQ 444

  Fly   495 ATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGPAKD 545
            |.||...|||.|||||:||.||.:.|:.||.||||:|:||::||||.|..|
  Rat   445 AAVPLSSETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	206/483 (43%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	208/465 (45%)
Alpg	XP_038940610.1	Alk_phosphatase	54..490	CDD:395188	208/465 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760