DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and Alp11

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	206/559 - (36%)
Similarity:	289/559 - (51%)	Gaps:	95/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVILGFLLGSLVAFSWAGVTTQPPPLIRTLSAGGDIGPQFDVGKTKEPED---AEFWHNVGLRQL 65
            |.|| |||.:|:......|     |::..:                :|.|   :..|    |||.
  Fly     8 LAIL-FLLHALIPILALSV-----PMVEQV----------------QPADELLSSHW----LRQA 46

  Fly    66 EKTIKQAQRVKEDSYQ--KKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPN 128
            :..:::.....:||..  ::|:|:::.:|||:.|:|::|.||.||| .:.|.||:..|..:.||.
  Fly    47 QSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLTAARILKGQ-RRGGRGEDAQLAVEQFPF 110

  Fly   129 TGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNGQQGRVQSVMEWAQKEGKRTG 193
            :|::|||.:|:|.||||.||||.|.|.|||.|.:|       ::|...||.||::|||:.||.||
  Fly   111 SGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVG-------QSGSGERVDSVLQWAQRAGKATG 168

  Fly   194 VVTTTRITHATPAATYAHIYDRDWECDTEVPAESVGFHVDIARQLVENAPGNRFNVILGGGMSPM 258
            ||||||:|.|:||..|||:..|             |..::|||||||..||...|||||||:...
  Fly   169 VVTTTRLTDASPAGAYAHVSRR-------------GEELEIARQLVEEEPGRNLNVILGGGLGKF 220

  Fly   259 GILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDLLNVNVKKVDHLM 323
                |.|               |.|.::|.|:|...:.|.....:|    |:|.|. ......|:
  Fly   221 ----ADE---------------RRDGKDLLAQWRESNPNGCFSRSL----KELRNC-TDATGTLL 261

  Fly   324 GLFRNNHITYSIAREAGEPSLQEMTETALGILER--GDESNGFVLLVEGGRIDQGHHMNYARAAL 386
            |:|.::|::|.:|.....|.|.:|...|:..|||  .::.||:.:.:||||||.|||......||
  Fly   262 GIFSDSHMSYHLAASKELPRLCDMAAAAIEKLERKSQEDGNGYFVFIEGGRIDHGHHETRVGYAL 326

  Fly   387 HELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETIS 451
            .|:.|||.|::..:..|||.:||::|||||||.::.:|||.||..|||........:.:.|.|::
  Fly   327 DEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMSGYAKRGTPILGMDAQQRDVNGVPYSTLN 391

  Fly   452 YANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGP 516
            ||.|.  |..|..|.|.::.|....|..:       .|:|.|    .||. .|.||||.|||.||
  Fly   392 YAIGK--WQSLDKDGRRESPSKTLSPTSY-------TPSYIH----GRKG-VHSGEDVVVFAMGP 442

  Fly   517 GSSLIRGVFEQNYLAYVMSYAGCLGPAKDFDDSCEDHKD 555
            .|.|..||.|||.|.::|.||.|||.....   |...||
  Fly   443 QSHLFGGVMEQNLLPHIMGYAACLGNGLTL---CNQDKD 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	185/477 (39%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	183/457 (40%)
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	183/457 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466679
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900