DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp4 and Alpl

DIOPT Version :9

Sequence 1:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_037191.2	Gene:	Alpl / 25586	RGDID:	2100	Length:	524	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	228/562 - (40%)
Similarity:	309/562 - (54%)	Gaps:	57/562 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LSAGGDIGPQFDVGKTKEPEDAEFWHNVGLRQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGI 97
            |:.|..:...|...|.|:|   .:|.    :|.::|:|.|.::::.: ...|:|||:|:|||||:
  Rat     8 LAIGTCLTNSFVPEKEKDP---SYWR----QQAQETLKNALKLQKLN-TNVAKNIIMFLGDGMGV 64

  Fly    98 STISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAI 162
            ||::|.||.||| |.|..|||..|..|.||...::||||.:.|||||||||||...|.|.:.|.:
  Rat    65 STVTAARILKGQ-LHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTV 128

  Fly   163 GMDAT--RSKKNGQQG-RVQSVMEWAQKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVP 224
            |:.|.  |::.|..|| .|.|::.||:..||..|:|||||:.||||:|.|||..||||..|.|:|
  Rat   129 GVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMP 193

  Fly   225 AESVGFHV-DIARQLVENAPGNRFNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLP 288
            .|::.... |||.||:.|.  ...:||:|||...|...|.::|:   :|...:...||.|..:|.
  Rat   194 PEALSQGCKDIAYQLMHNI--KDIDVIMGGGRKYMYPKNRTDVE---YELDEKARGTRLDGLDLI 253

  Fly   289 AEWLA-----HHANDTVPPALVHNRKDLLNVNVKKVDHLMGLFRNNHITYSIAR-EAGEPSLQEM 347
            :.|.:     .|::      .|.||.:||.::..:||:|:|||....:.|.:.| ...:|||.||
  Rat   254 SIWKSFKPRHKHSH------YVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEM 312

  Fly   348 TETALGILERGDESNGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILV 412
            .|.||.||.:..:  ||.|||||||||.|||...|:.||||..|.|.||..|...|...:||.:|
  Rat   313 VEVALRILTKNPK--GFFLLVEGGRIDHGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTLTVV 375

  Fly   413 TADHSHAVTFNGYALRGADILGTANSHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMP 477
            ||||||..||.||..||..|.|.|......|...:..|.|.|||||   ...|...:|.|.:
  Rat   376 TADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGY---KVVDGERENVSMV--- 434

  Fly   478 LKHFTAEERAAPTYRHLATVPRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLGP 542
                   :.|...|:..:.||.:.||||||||||||.||.:.|:.||.||||:.:||:||.|:|.
  Rat   435 -------DYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGA 492

  Fly   543 AKDFDDSCEDHKDGQKDRPLDKPNPKRNGATVVGASLIPILT 584
            ..   |.|......      ..|:|   ||.::..:|.|:.|
  Rat   493 NL---DHCAWASSA------SSPSP---GALLLPLALFPLRT 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	206/483 (43%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	206/465 (44%)
Alpl	NP_037191.2	Alk_phosphatase	51..490	CDD:395188	206/465 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660